Buthus lienhardi venom and pathophysiological effects at the histological, hematological, biochemical and motor skills levels
| Autor: | Mehdi Ait Laaradia, Abderrahman Chait, Moulay Abdelmonaim El Hidan, Sara Oufquir, Fatimazahra Marhoume, Ali Boumezzough, Zahra Sokar, Btissam Bouimeja |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Injections Subcutaneous Scorpion Venoms Venom Pharmacology Kidney Toxicology complex mixtures Nephrotoxicity Lethal Dose 50 Scorpions Mice 03 medical and health sciences Subcutaneous injection 0302 clinical medicine medicine Animals Lung 030102 biochemistry & molecular biology business.industry Hepatotoxin Heart Histology Pathophysiology Blood Cell Count Enzymes Liver Motor Skills Toxicity Histopathology business 030217 neurology & neurosurgery |
| Zdroj: | Toxicon. 146:106-113 |
| ISSN: | 0041-0101 |
| Popis: | The present study investigated the toxic effects of B. lienhardi venom, at the histological, hematological, biochemical and motor skill levels following a subcutaneous injection of different doses of venom. The LD50 of B. lienhardi scorpion venom was found to be 0.27 mg/Kg by subcutaneous injection route. The results clearly indicate that B. lienhardi venom induces massive tissue damages in the organs, such as lungs, heart, kidneys and liver together with hematological impairments manifested by decreased levels of both red and white series. We further demonstrated that scorpion venom is able to alter motor system by inducing motor incoordination and reducing muscle strength. The overall results confirm that the venom from B. lienhardi primarily is a highly toxic agent and has cardiotoxic, nephrotoxic, hepatotoxic and pneumotoxic activity. |
| Databáze: | OpenAIRE |
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