Uniform, Large-Area, Highly Ordered Peptoid Monolayer and Bilayer Films for Sensing Applications
Autor: | Jae Hong Kim, Elissa M. Grzincic, Adam R. Abate, Daniel J. Murray, Ronald N. Zuckermann, Samuel Kim |
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Rok vydání: | 2019 |
Předmět: |
Solid-state chemistry
Materials science Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Nanomaterials chemistry.chemical_compound Molecular recognition Monolayer Electrochemistry General Materials Science Spectroscopy chemistry.chemical_classification Chemical Physics Bilayer Peptoid Surfaces and Interfaces Polymer 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences chemistry Electron diffraction 0210 nano-technology Biotechnology |
Zdroj: | Langmuir : the ACS journal of surfaces and colloids, vol 35, iss 42 |
ISSN: | 1520-5827 |
Popis: | The production of atomically defined, uniform, large-area 2D materials remains as a challenge in materials chemistry. Many methods to produce 2D nanomaterials suffer from limited lateral film dimensions, lack of film uniformity, or limited chemical diversity. These issues have hindered the application of these materials to sensing applications, which require large-area uniform films to achieve reliable and consistent signals. Furthermore, the development of a 2D material system that is biocompatible and readily chemically tunable has been a fundamental challenge. Here, we report a simple, robust method for the production of large-area, uniform, and highly tunable monolayer and bilayer films, from sequence-defined peptoid polymers, and their application as highly selective molecular recognition elements in sensor production. Monolayers and bilayer films were produced on the centimeter scale using Langmuir-Blodgett methods and exhibited a high degree of uniformity and ordering as evidenced by atomic force microscopy, electron diffraction, and grazing incidence X-ray scattering. We further demonstrated the utility of these films in sensing applications by employing the biolayer interferometry technique to detect the specific binding of the pathogen derived proteins, shiga toxin and anthrax protective antigen, to peptoid-coated sensors. |
Databáze: | OpenAIRE |
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