Acute encephalopathy associated with continuous vincristine sulfate combination therapy: case report
| Autor: | Eva Maida, Heinz Ludwig, Werner Scheithauer |
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| Rok vydání: | 1985 |
| Předmět: |
Vincristine
Vincristine Sulfate Side effect Combination therapy Fulminant Encephalopathy Dexamethasone Orthostatic vital signs Antineoplastic Combined Chemotherapy Protocols Medicine Humans Pharmacology (medical) Pharmacology Brain Diseases business.industry Middle Aged medicine.disease Oncology Doxorubicin Anesthesia Female business Multiple Myeloma medicine.drug |
| Zdroj: | Investigational new drugs. 3(3) |
| ISSN: | 0167-6997 |
| Popis: | Neurotoxicity is a well-recognized and commonly observed side effect associated with the use of vincristine sulfate in cancer chemotherapy. The clinical manifestations of vincristine neuropathy cover a wide spectrum of peripheral neurologic dysfunctions that have been described to be reversible and cumulative in most instances (1, 2). Paresthesias, loss of tendon reflexes, and progressive weakness are the most common clinical features (3, 4). Sensory impairment, cranial nerve palsies, gastrointestinal disturbances, and autonomie dysfunctions including atonic bladder, impotence, and orthostatic hypotension may occur (5). Acute CNS complications, usually presenting as generalized seizures, are extremely rare and only a few cases have been reported which were without underlying biochemical or structural abnormalities (1, 5–9). We describe the case of a woman with multiple myeloma, who developed fulminant encephalopathy following 4 days of continuous vincristine, adriamycin, and day 1–4 pulse dexamethasone (VAD) combination therapy. |
| Databáze: | OpenAIRE |
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