Pupillary and vascular effects of calcium antagonists in migraine
| Autor: | Umberto Pietrini, B.M. Fusco, Marcello Fanciullacci, Francesca Cangi, Maria Boccuni, Gaetano Gatto, Simone Marabini |
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| Rok vydání: | 1985 |
| Předmět: |
Mean arterial pressure
Nifedipine Migraine Disorders chemistry.chemical_element Blood Pressure Calcium Pharmacology Cinnarizine 03 medical and health sciences 0302 clinical medicine medicine Mydriasis Humans 030212 general & internal medicine Flunarizine business.industry Pupil General Medicine medicine.disease Calcium Channel Blockers Blood pressure chemistry Migraine Verapamil Vasoconstriction Anesthesia Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cephalalgia : an international journal of headache. 5 |
| ISSN: | 0333-1024 |
| Popis: | In migraine patients the effects of calcium antagonists (flunarizine, verapamil and nifedipine) on both venous and pupillary neuromuscular functions, as well as on blood pressure have been evaluated. A single oral dose of flunarizine (10 mg) and verapamil infusion (50 μg/ml/min) increased venous compliance. Verapamil also counteracted dose-dependent dopamine induced venoconstriction. Nifedipine (10 mg orally) reduced mean arterial pressure in upright position in migraineurs but not in controls. In addition, chronic treatment with flunarizine (10 mg for 2 weeks) induced a transient miotic effect and a reduction of tyramine induced mydriasis. These findings demonstrated that calcium antagonists affect vascular and extra-vascular structures. It is postulated that, in migraine, calcium entry blockers may prevent exaggerated responses to catecholaminergic stimulation. |
| Databáze: | OpenAIRE |
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