Multiple roles of Sonic Hedgehog in the developing human cortex are suggested by its widespread distribution
| Autor: | Nevena V. Radonjić, Nada Zecevic, Fani Memi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Human fetal brain 0301 basic medicine SHH receptors animal structures Histology PAX6 Transcription Factor Gestational Age 03 medical and health sciences Fetus 0302 clinical medicine Holoprosencephaly Cortex (anatomy) Glial Fibrillary Acidic Protein medicine Humans Hedgehog Proteins RNA Messenger Progenitor cell Sonic hedgehog gamma-Aminobutyric Acid Cerebral Cortex Neurons biology Glutamate Decarboxylase General Neuroscience Age Factors Brain Human brain medicine.disease Corticogenesis Ki-67 Antigen 030104 developmental biology medicine.anatomical_structure Cerebral cortex embryonic structures biology.protein Female Original Article Anatomy T-Box Domain Proteins Neuroglia Neuroscience Morphogen 030217 neurology & neurosurgery |
| Zdroj: | Brain Structure & Function |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-018-1621-5 |
| Popis: | Sonic Hedgehog (Shh) plays an instrumental role in brain development, fine-tuning processes such as cell proliferation, patterning, and fate specification. Although, mutations in the SHH pathway in humans are associated with various neurodevelopmental disorders, ranging from holoprosencephaly to schizophrenia, its expression pattern in the developing human brain is not well established. We now determined the previously not reported wide expression of SHH in the human fetal cerebral cortex during most of the gestation period (10–40 gestational weeks). This spatiotemporal distribution puts Shh in a position to influence the fundamental processes involved in corticogenesis. SHH expression increased during development, shifting from progenitor cells in the proliferative zones to neurons, both glutamatergic and GABAergic, and astrocytes in upper cortical compartments. Importantly, the expression of its downstream effectors and complementary receptors revealed evolutionary differences in SHH-pathway gene expression between humans and rodents. Electronic supplementary material The online version of this article (10.1007/s00429-018-1621-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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