Correlation of Zinc with Oxidative Stress Biomarkers
| Autor: | Agustín Llopis-González, Raul Lopez-Izquierdo, María Morales-Suárez-Varela, Veronica Gonzalez-Albert, Javier F Chaves, Vicente Huerta-Biosca, Juan Carlos Martín-Escudero, Isabel Gonzalez-Manzano |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Farmacologia hypertension Adolescent Cross-sectional study Health Toxicology and Mutagenesis lcsh:Medicine Physiology chemistry.chemical_element Urine Zinc medicine.disease_cause Article Young Adult chemistry.chemical_compound Risk Factors medicine Humans oxidative stress Young adult Risk factor Cellular Senescence Aged Aged 80 and over Glutathione Disulfide business.industry lcsh:R zinc Public Health Environmental and Occupational Health Middle Aged Salut pública Surgery cellular aging Cross-Sectional Studies chemistry Spain Glutathione disulfide Female business Cell aging Biomarkers Oxidative stress |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 12 Issue 3 Pages 3060-3076 MoralesSuárez-Varela, María Llopis González, Agustín González Albert, Verónica López Izquierdo, Raúl González Manzano, Isabel Cháves, Javier Huerta Biosca, Vicente Martin Escudero, Juan Carlos 2015 Correlation of Zinc with Oxidative Stress Biomarkers International Journal Of Environmental Research And Public Health 12 3060 3076 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname International Journal of Environmental Research and Public Health, Vol 12, Iss 3, Pp 3060-3076 (2015) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph120303060 |
| Popis: | Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual’s physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20–59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson’s C = 0.639 p = 0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile OR = 2.80 (95%CI = 1.09–7.18) and AOR = 3.06 (95%CI = 0.96–9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension. |
| Databáze: | OpenAIRE |
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