Multiple aortic aneurysms complicated by a rupture in the systemic lupus erythematosus: A case report
Autor: | Yasunori Fujioka, Yuichi Terado, Junichiro Sato, Kazuhito Fukuoka, Yasuo Ohkura, Kimimasa Nakabayashi, Takako Ohtsuka, Tomohiro Kawakami, Kazuhiko Hirano, Kenichi Yokoyama, Atsushi Kurata |
---|---|
Rok vydání: | 2008 |
Předmět: |
Adult
medicine.medical_specialty Aortic Rupture Autopsy Pathology and Forensic Medicine Aortic aneurysm Fatal Outcome Aneurysm Adrenal Cortex Hormones Antiphospholipid syndrome medicine Humans Lupus Erythematosus Systemic Age of Onset Aortic rupture Aortic dissection Lupus erythematosus business.industry Cell Biology Middle Aged Antiphospholipid Syndrome medicine.disease Thrombosis Surgery Aortic Dissection Female business Aortic Aneurysm Abdominal |
Zdroj: | Pathology - Research and Practice. 204:845-850 |
ISSN: | 0344-0338 |
DOI: | 10.1016/j.prp.2008.05.009 |
Popis: | We report the case of a 61-year-old female who suffered from systemic lupus erythematosus (SLE) and died of a ruptured abdominal aortic aneurysm (AA). She was diagnosed to have SLE at 39 years of age, and was administrated steroids and prostaglandin E(2). From 52 years of age, AA, peripheral arterial occlusion, and multiple organ infarctions appeared repeatedly. At 59 years of age, she was found to be affected by antiphospholipid antibody syndrome (APS). In the following year, expansion of an abdominal AA was identified, but she was given only conservative treatment. In the next year, sudden epigastralgia and dyspnea occurred, and she died. An autopsy revealed multiple AAs up to 11 cm in diameter, one of which showed ruptures, forming a retroperitoneal hematoma. Marked atherosclerosis of the aorta was noted, and she also had aortic dissection accompanied by cystic medial necrosis (CMN). An old myocardial infarction and brain infarction were also confirmed. Although SLE with APS is common, a complication of the disease by CMN, multiple AAs, or ruptured AA has been described in several cases to date. Regarding the etiology of this complicated presentation, we presume synergistic involvement of various factors, such as atherosclerosis and CMN associated with SLE, thrombosis due to APS, and prolonged steroid therapy. |
Databáze: | OpenAIRE |
Externí odkaz: |