Evaluation of MARK BTM for Quantitative Measurement of Three Tumor Markers: Prostate Specific Antigen, Alpha Fetoprotein, and Carcinoembryonic Antigen
| Autor: | Ho-Seong Han, Hyundoo Hwang, Kil Hwan Kim, Jaesik Kim, Jaekyu Choi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty General Biochemistry Genetics and Molecular Biology Carcinoembryonic antigen Internal medicine medicine Biomarkers Tumor Humans Tumor marker Immunoassay biology medicine.diagnostic_test business.industry Cancer Reproducibility of Results Electrochemical Techniques Prostate-Specific Antigen medicine.disease Carcinoembryonic Antigen Clinical Practice Prostate-specific antigen Electrochemical immunoassay biology.protein alpha-Fetoproteins Alpha-fetoprotein business |
| Zdroj: | Clinical laboratory. 65(8) |
| ISSN: | 1433-6510 |
| Popis: | Background Tumor marker assays have played a crucial role for screening cancers and monitoring cancer patients, as they reflect the status and prognosis of patients. Alpha fetoprotein (AFP), prostate specific antigen (PSA), and carcinoembryonic antigen (CEA) are the most commonly used tumor marker proteins. The MARK BTM immunoassay system is a novel platform based on magnetic nanoparticles and electrochemical immunoassay. Methods The analytical performance of MARK BTM immunoassay system for determination of AFP, PSA, and CEA are evaluated. Comparisons of methods are also conducted by comparing the assay results of MARK BTM immunoassay system to that of cobas e 801 system. Results The MARK BTM immunoassay system provides within-run, between-run, and between-day precisions for the three tumor markers, ranging from 1.13 - 7.46%. Data measured by the MARK BTM immunoassay system show high correlation with that of the cobas e 801 system, with a linear slope ranging from 0.966 to 1.042 and a correlation coefficient of r > 0.996 for the three markers. Conclusions These results show that the MARK BTM immunoassay system can be used for the quantitative measurements of AFP, PSA, and CEA in clinical practice. |
| Databáze: | OpenAIRE |
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