Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
| Autor: | Patrice G. Guyenet, Douglas A. Bayliss, Seth D. DePuy, Stephen B. G. Abbott, Michal G. Fortuna, Ruth L. Stornetta |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chemoreceptor Physiology Nerve net Automaticity Biology Models Biological Article Glutamatergic Parafacial medicine Animals Respiratory system Homeodomain Proteins Central chemoreceptors Respiration General Neuroscience Carbon Dioxide Hydrogen-Ion Concentration Respiratory Center Chemoreceptor Cells Phrenic Nerve medicine.anatomical_structure Breathing Nerve Net Neuroscience Transcription Factors |
| Zdroj: | Respiratory Physiology & Neurobiology. 168:59-68 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2009.02.001 |
| Popis: | Breathing automaticity and CO(2) regulation are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO(2) constant. This review updates the analysis presented in prior publications. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is presented, but this is only one of many factors that determine their activity. The RTN is also regulated by powerful inputs from the carotid bodies and, at least in the adult, by many other synaptic inputs. We also analyze how RTN neurons may control the activity of the downstream central respiratory pattern generator. Specifically, we review the evidence which suggests that RTN neurons (a) innervate the entire ventral respiratory column and (b) control both inspiration and expiration. Finally, we argue that the RTN neurons are the adult form of the parafacial respiratory group in neonate rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect