Adipose Triglyceride Lipase (ATGL) Expression Is Associated with Adiposity and Tumor Stromal Proliferation in Patients with Pancreatic Ductal Adenocarcinoma
| Autor: | Xianzhong Ding, Yongxin Chen, Joanne K. Rutgers, Ping Hou, Jinping Lai, Mona Cornwell, Susan E. Crawford, Marshall W. Meeks, Shane Grace |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Stromal cell endocrine system diseases Biology 03 medical and health sciences chemistry.chemical_compound Pancreatectomy Breast cancer Internal medicine Biomarkers Tumor medicine Humans Obesity Risk factor Adiposity Aged Cell Proliferation Chi-Square Distribution Triglyceride Lipase General Medicine Middle Aged medicine.disease Immunohistochemistry digestive system diseases Pathophysiology Pancreatic Neoplasms 030104 developmental biology Endocrinology Oncology chemistry Adipose triglyceride lipase Female Carcinoma Pancreatic Ductal |
| Zdroj: | Anticancer Research. 37:699-704 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background: Obesity is an established risk factor for the development of pancreatic ductal adenocarcinoma (PDAC). However, the pathophysiology of how increased adiposity increases the risk for PDAC has not been fully elucidated. Adipose triglyceride lipase (ATGL) is a lipase that catabolizes triglyceride hydrolysis and has been implicated in the development of breast cancer. We hypothesized that overweight patients with PDAC would demonstrate higher tumor ATGL expression compared to non-overweight patients with PDAC. Materials and Methods: Immunohistochemical analysis for ATGL expression was performed on PDAC tissues from 44 patients after Whipple procedure or distal pancreatectomy. Correlation of ATGL expression with clinicopathological features was evaluated. Results: A total of 23/44 (52.2%) PDACs showed low level ATGL immunoreactivity, while 21/44 (47.8%) showed a high level, with moderate to strong positive ATGL immunoreactivity in more than 50% of the tumor cells. Chi-squared testing revealed a statistically significant association between high ATGL expression and both BMI >25 kg/m2 (χ2=5.74, p=0.017) and increased tumor stroma (χ2=19.14, p |
| Databáze: | OpenAIRE |
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