Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis
| Autor: | Huai Seng Loh, Anne Yee, Huai Heng Loh, Lee Ling Lim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
lcsh:RC435-571 Levothyroxine Cohort Studies 03 medical and health sciences 0302 clinical medicine Hypothyroidism Subclinical hypothyroidism Internal medicine lcsh:Psychiatry Thyroid stimulating hormone medicine Prevalence Humans Euthyroid 030212 general & internal medicine Depression (differential diagnoses) Subclinical infection Psychiatric Status Rating Scales business.industry Depression Beck Depression Inventory Odds ratio 030227 psychiatry Psychiatry and Mental health Relative risk Case-Control Studies Cohort business medicine.drug Research Article |
| Zdroj: | BMC Psychiatry BMC Psychiatry, Vol 19, Iss 1, Pp 1-10 (2019) |
| ISSN: | 1471-244X |
| Popis: | Background Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism (SCH) is controversial. To date, there is a lack of data on the improvement of depressive symptoms with levothyroxine therapy among individuals with coexistent SCH. Methods We conducted a meta-analysis to evaluate the association between SCH and depression including 1) the prevalence of depression in SCH (with a sub-analysis of the geriatric cohort), 2) thyroid stimulating hormone (TSH) level among patients with depression and 3) the effect of levothyroxine therapy among patients with SCH and coexistent depression. Results In a pooled analysis of 12,315 individuals, those with SCH had higher risk of depression than euthyroid controls (relative risk 2.35, 95% confidence intervals [CI], 1.84 to 3.02; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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