Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model
| Autor: | Raif Özden, Suzan Aydın, Murat Karcioglu, Isil Davarci, Ali Sarı, Fatih Sefil, Kasım Tuzcu, Akin Aydogan |
|---|---|
| Přispěvatelé: | Hatay Mustafa Kemal Üniversitesi |
| Jazyk: | turečtina |
| Rok vydání: | 2014 |
| Předmět: |
Resuscitation
Fat Emulsions Intravenous Epinephrine medicine.medical_treatment Coronary circulation Random Allocation Bolus (medicine) Coronary Circulation medicine Animals Vasoconstrictor Agents Asystole Anesthetics Local Saline Phospholipids Cerrahi Levobupivacaine Key words: Levobupivacaine lipid emulsion epinephrine toxicity resuscitation business.industry Advanced cardiac life support General Medicine medicine.disease Bupivacaine Heart Arrest Soybean Oil Disease Models Animal medicine.anatomical_structure Anesthesia Drug Therapy Combination Emulsions Rabbits business medicine.drug |
| Zdroj: | Volume: 44, Issue: 2 330-336 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Aim: Cardiac toxicity due to the administration of local anesthetics may be fatal. In this study, we evaluated the efficacy of a 20% lipid solution combined with epinephrine in a levobupivacaine-induced cardiac arrest model. Materials and methods: A total of 14 New Zealand rabbits were sedated and mechanically ventilated. Asystole was induced with intravenous levobupivacaine injection. The rabbits were randomized into groups receiving the same volume of either 0.9% saline (CR group) or a 20% lipid solution (LE group) along with a 100 µg/kg epinephrine bolus, which were administered immediately upon asystole. Standard advanced cardiac life support protocols were performed. Results: Four subjects in the LE group as well as 3 subjects in the CR group had a spontaneous recovery (P = 0.592). In the 20th minute after arrest, 3 subjects in the LE group had maintained spontaneous circulation, while there was only 1 subject from the CR group with the same outcome. Conclusion: We found that adding a lipid solution to epinephrine for the resuscitation of rabbits that underwent levobupivacaineinduced cardiac arrest increased recovery rates of circulation and therefore the likelihood of survival. Further studies are needed to develop clinical therapies for the systemic toxicity of local anesthetics. |
| Databáze: | OpenAIRE |
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