Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
| Autor: | Wolfgang Ummenhofer, Mathias Sluga, Martin Siegemund, Stephan Marsch, Wolfgang Studer |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Endotracheal intubation Succinylcholine law.invention Randomized controlled trial law medicine Intubation Intratracheal Intubation Humans In patient Anesthesia Androstanols Prospective Studies Rocuronium Aged business.industry Significant difference Middle Aged Rapid sequence induction Surgery Anesthesiology and Pain Medicine Neuromuscular Depolarizing Agents Female Emergencies Propofol business medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | Anesthesia and analgesia. 101(5) |
| ISSN: | 0003-2999 |
| Popis: | When anesthesia is induced with propofol in elective cases, endotracheal intubation conditions are not different between succinylcholine and rocuronium approximately 60 s after the injection of the neuromuscular relaxant. In the present study, we investigated whether, in emergent cases, endotracheal intubation conditions obtained at the actual moment of intubation under succinylcholine differ from those obtained 60 s after the injection of rocuronium. One-hundred-eighty adult patients requiring rapid sequence induction of anesthesia for emergent surgery received propofol (1.5 mg/kg) and either rocuronium (0.6 mg/kg; endotracheal intubation 60 s after injection) or succinylcholine (1 mg/kg; endotracheal intubation as soon as possible). The time from beginning of the induction until completion of the intubation was shorter after the administration of succinylcholine than after rocuronium (median time 95 s versus 130 s; P < 0.0001). Endotracheal intubation conditions, rated with a 9-point scale, were better after succinylcholine administration than after rocuronium (8.6 +/- 1.1 versus 8.0 +/- 1.5; P < 0.001). There was no significant difference in patients with poor intubation conditions (7 versus 12) or in patients with failed first intubation attempt (4 versus 5) between the groups. We conclude that during rapid sequence induction of anesthesia in emergent cases, succinylcholine allows for a more rapid endotracheal intubation sequence and creates superior intubation conditions compared with rocuronium. |
| Databáze: | OpenAIRE |
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