Suppression of Mammary Carcinogenesis Through Early Exposure to Dietary Lipotropes Occurs Primarily In Utero
| Autor: | Kyongshin Cho, Kwangbog Cho, Courtney Crane, Raushan K. Singh, Chung S. Park, Woo-Sik Choi, Lawrence Mabasa |
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| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
medicine.medical_specialty Offspring Medicine (miscellaneous) Mammary Neoplasms Animal Histone Deacetylases Choline Rats Sprague-Dawley chemistry.chemical_compound Folic Acid Methionine Pregnancy Lactation Internal medicine medicine Animals Vitamin B12 Maternal-Fetal Exchange Nutrition and Dietetics biology Methylnitrosourea Chromatin Assembly and Disassembly medicine.disease Enzyme assay Diet Rats Vitamin B 12 Endocrinology medicine.anatomical_structure Animals Newborn Oncology chemistry In utero biology.protein Female |
| Zdroj: | Nutrition and Cancer. 67:1278-1284 |
| ISSN: | 1532-7914 0163-5581 |
| Popis: | The study determined whether feeding during lactation affects the suppressive effect of maternal dietary lipotropes (i.e., methionine, choline, folate, and vitamin B12) on mammary carcinogenesis. Pregnant Sprague-Dawley rats were randomly allocated to the control diet during pregnancy and lactation (CC), lipotropes-fortified diet during pregnancy (LC), lipotropes-fortified diet during pregnancy plus lactation (LL), or lipotropes-fortified diet during lactation (CL). Randomly selected female offspring from each group were injected intraperitoneally with 50 mg/kg body weight of N-nitroso-N-methylurea at 50 days of age to induce mammary tumors. The LC and LL diets significantly increased tumor latency and survival (P < 0.05). Tumor volumes were significantly suppressed in LC and LL offspring as compared with the CC and CL pups (3759.1 ± 563.0 and 3603.7 ± 526.1 vs. 7465.0 ± 941.1 and 5219.3 ± 759.8 mm(3), respectively; P < 0.05). Both LC and LL lowered tumor multiplicity as compared with CC and CL (P < 0.05). The LC and LL diets repressed transcription of histone deacetylase (HDAC) 1 as well as total HDAC enzyme activity as compared with CC and CL diets (P < 0.05). Data suggest that the tumor suppressive effect of maternal dietary lipotropes is primarily in utero and may be linked to regulation of proteins involved in chromatin remodeling. |
| Databáze: | OpenAIRE |
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