Modeling of Interstitial Ultrasound Ablation for Continuous Applicator Rotation With MR Validation
| Autor: | Everette C. Burdette, Desmond T.B. Yeo, Gregory S. Fischer, Paulo A. W. G. Carvalho, Paul Neubauer, Chitresh Bhushan, Matthew Tarasek, Zhanyue Zhao, Emery Williams, Katie Y. Gandomi, Julie G. Pilitsis, Eric Fiveland, Christopher J. Nycz |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Rotation Swine medicine.medical_treatment Ultrasonic Therapy 0206 medical engineering Biomedical Engineering 02 engineering and technology Imaging phantom Article Magnetic Resonance Thermal Imaging medicine Animals Image resolution Ultrasonography Therapeutic ultrasound business.industry Phantoms Imaging Ultrasound Ablation 020601 biomedical engineering Magnetic Resonance Imaging Finite element method business Biomedical engineering |
| Zdroj: | IEEE Trans Biomed Eng |
| ISSN: | 1558-2531 |
| Popis: | The primary objective of cancer intervention is the selective removal of malignant cells while conserving surrounding healthy tissues. However, the accessibility, size and shape of the cancer can make achieving appropriate margins a challenge. One minimally invasive treatment option for these clinical cases is interstitial needle based therapeutic ultrasound (NBTU). In this work, we develop a finite element model (FEM) capable of simulating continuous rotation of a directional NBTU applicator. The developed model was used to simulate the thermal deposition for different rotation trajectories. The actual thermal deposition patterns for the simulated trajectories were then evaluated using magnetic resonance thermal imaging (MRTI) in a porcine skin gelatin phantom. An MRI-compatible robot was used to control the rotation motion profile of the physical NBTU applicator to match the simulated trajectory. The model showed agreement when compared to experimental measurements with Pearson correlation coefficients greater than 0.839 when comparing temperature fields within an area of 12.6 mm radius from the ultrasound applicator. The average temperature error along a 6.3 mm radius profile from the applicator was $1.27\;^\circ\mathrm{C}$ . The model was able to compute 1 s of thermal deposition by the applicator in 0.2 s on average with a 0.1 mm spatial resolution and 0.5 s time steps. The developed simulation demonstrates performance suitable for real-time control which may enable robotically-actuated closed-loop conformal tumor ablation. |
| Databáze: | OpenAIRE |
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