Mathematical modeling and experimental analysis of the efficacy of photodynamic therapy in conjunction with photo thermal therapy and PEG-coated Au-doped TiO2 nanostructures to target MCF-7 cancerous cells
| Autor: | Yu-Ming Chu, Muhammad Suleman Rana, Hijaz Ahmad, Amanullah Fatehmulla, Muhammad Fakhar-e-Alam, Khurram Saleem Alimgeer, Muhammad Atif, Atif Hanif, W. A. Farooq, Nafeesah Yaqub, Seemab Iqbal, Shafiq Ahmad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Biodistribution Materials science Nanostructure Photodynamic therapy (PDT) MCF-7 cancerous cells Population chemistry.chemical_element Nanotechnology Polyethylene glycol RMSE Root mean square error 01 natural sciences TEM Transmission electron microscope 03 medical and health sciences chemistry.chemical_compound Photothermal therapy/(HET) NRA Neutral red assay PEG-coated Au-doped Titanium oxide (TiO2) nanostructures education lcsh:QH301-705.5 education.field_of_study technology industry and agriculture Photothermal therapy Titanium oxide 030104 developmental biology chemistry lcsh:Biology (General) PEG Polyethylene glycol Colloidal gold Original Article General Agricultural and Biological Sciences 010606 plant biology & botany Titanium SPR Surface plasmon resonance |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 28, Iss 2, Pp 1226-1232 (2021) |
| ISSN: | 2213-7106 1319-562X |
| Popis: | Some nanoscale morphologies of titanium oxide nanostructures blend with gold nanoparticles and act as satellites and targeted weapon methodologies in biomedical applications. Simultaneously, titanium oxide can play an important role when combined with gold after blending with polyethylene glycol (PEG). Our experimental approach is novel with respect to the plasmonic role of metal nanoparticles as an efficient PDT drug. The current experimental strategy floats the comprehensive and facile way of experimental strategy on the critical influence that titanium with gold nanoparticles used as novel photosensitizing agents after significant biodistribution of proposed nanostructures toward targeted site. In addition, different morphologies of PEG-coated Au-doped titanium nanostructures were shown to provide various therapeutic effects due to a wide range of electromagnetic field development. This confirms a significantly amplified population of hot electron generation adjacent to the interface between Au and TiO2 nanostructures, leading to maximum cancerous cell injury in the MCF-7 cell line. The experimental results were confirmed by applying a least squares fit math model which verified our results with 99% goodness of fit. These results can pave the way for comprehensive rational designs for satisfactory response of performance phototherapeutic model mechanisms along with new horizons of photothermal therapy (HET) and photodynamic therapy (HET) operating under visible and near-infrared (NIR) light. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|