The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid
| Autor: | Ałła Graban, Beata Lipska, Magdalena Restel, Anna Bochyńska, Waldemar Lechowicz, Danuta Ryglewicz, Wanda Lipczyńska-Łojkowska, Magdalena Gugała-Iwaniuk |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty Hyperhomocysteinemia Homocysteine Adolescent media_common.quotation_subject Clinical Neurology Gastroenterology Epilepsy chemistry.chemical_compound Young Adult Folic Acid Internal medicine medicine Humans Vitamin B12 media_common Aged Valproic Acid business.industry Beck Depression Inventory General Medicine Carbamazepine Middle Aged medicine.disease Vitamin B 12 Neurology chemistry Dietary Supplements Vitamin B Complex Physical therapy Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Seizure. 21(4) |
| ISSN: | 1532-2688 |
| Popis: | Purpose To investigate the influence of vitamin B supplementation on the plasma total homocysteine (p-tHcy), serum folate (s-FA), serum B12 (s-B12), and clinical state of patients with chronic epilepsy. Methods Beck Depression Inventory (BDI) scores and p-tHcy, s-B12, and s-FA levels were assessed at baseline, after 1 year of supplementation (G1), and before and after 1 year of VPA or CBZ therapy (G2). Results Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2). At baseline, mean p-tHcy level was significantly higher in G1 than G2 ( p =0.0001) with no significant differences in s-FA or s-B12 levels. p-tHcy level significantly decreased in CBZ-treated G1 patients ( p =0.00002) after 1 year of supplementation and increased in G2 after 1 year of anti-epileptic drug (AED) therapy without supplementation. BDI scores in G1 decreased significantly after 1 year of supplementation ( p =0.0001) and increased significantly in VPA-treated G2 patients after 1 year of AED therapy ( p =0.02). The number of hyperhomocysteinemic patients significantly decreased in G1 after vitamin B supplementation ( p =0.01) and increased in G2 ( p =0.002). We also observed improved BDI scores and reduced seizure frequency in patients with chronic epilepsy. Conclusions These data support the hypothesis that AEDs play a major role in hyperhomocysteinemia development in patients with epilepsy. Adding folate and vitamin B12 to AED therapy is a safe and inexpensive way to reduce the risk of hyperhomocysteinemia. |
| Databáze: | OpenAIRE |
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