Association of Anterior Uveitis With Acute Zika Virus Infection in Adults
| Autor: | Guilhem Cartry, Bahram Bodaghi, Yacine Troumani, Sara Touhami, Marie-Hélène Errera, Timothy L Jackson, Thierry David, L. Beral, Dominique Rousset, Camila V. Ventura, Dinu Stanescu-Segall |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Intraocular pressure medicine.medical_specialty Time Factors Slit Lamp Microscopy medicine.disease_cause Risk Assessment 01 natural sciences Disease Outbreaks Dengue fever Serology Zika virus Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Chikungunya 0101 mathematics Guadeloupe Intraocular Pressure Vision Ocular Slit Lamp biology Zika Virus Infection business.industry 010102 general mathematics Retrospective cohort study Prognosis medicine.disease biology.organism_classification Uveitis Anterior Dermatology Ophthalmology 030221 ophthalmology & optometry Female Ocular Hypertension Red eye medicine.symptom business Uveitis |
| Zdroj: | JAMA Ophthalmology. 139:95 |
| ISSN: | 2168-6165 |
| DOI: | 10.1001/jamaophthalmol.2020.5131 |
| Popis: | Importance Acute anterior uveitis has been reported to be associated with Zika virus (ZIKV) infection in case reports and retrospective studies based on systemic clinical signs of ZIKV and positive serologic tests. Objective To describe the ophthalmic findings associated with systemic ZIKV infection during the 2016 ZIKV outbreak in Guadeloupe in the French West Indies. Design, setting, and participants This cohort study assessed adult patients with red eye and virologic or serologic confirmation of acute ZIKV infection who were admitted to the Pointe-a-Pitre University Hospital from January 1, 2016, to January 1, 2017, for a systematic ophthalmologic examination. All patients with anterior uveitis also underwent a complete uveitis workup to rule out other causes of uveitis. Patients were excluded from the study if they had active uveitis and a history of uveitis or positive serology for other infectious diseases including dengue fever virus and chikungunya virus. Data were analyzed from January 1, 2016, to January 1, 2017. Exposures Patients with confirmed ZIKV infection underwent full ophthalmic examination at study inception and 3, 6, and 12 months. Main outcomes and measures Description of the presenting ocular characteristics, management, and outcome. Results Of 62 total patients with a red eye, 32 (51.6%) had no uveitis (mean [SD] age, 27.8 [3.7] years; 26 women [81.3%]) and 30 (48.4%) had anterior uveitis (mean [SD] age, 27.5 [3.8] years; 26 women [86.7%]), which was bilateral in all cases. Acute anterior uveitis was nongranulomatous and without synechiae, exhibiting mild anterior chamber reaction with small keratic precipitates. Ocular hypertension occurred in 25 patients (83.3%) with uveitis at presentation and persisted in 15 patients (50%) at 1 year despite antiglaucoma therapy and control of uveitis. Uveitis responded to topical steroids in all cases. Intraocular pressure was within normal limits for all patients without uveitis throughout the follow-up period. Conclusions and relevance Anterior uveitis was present in almost half of patients with a red eye and acute systemic ZIKV infection; the uveitis was usually bilateral and often associated with increased intraocular pressure. These results suggest that ophthalmic evaluation should be performed in patients with red eye and acute ZIKV infection to potentially detect and manage hypertensive anterior uveitis. |
| Databáze: | OpenAIRE |
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