Relationship between Discrimination Tasks of the Cantab and the Corpus Callosum Morphology in Alzheimer's Disease
| Autor: | Jacques Beau, Michel Zanca, Bruno Dubois, Michel Duyme, Agnès A. Dorion |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Population Experimental and Cognitive Psychology Neuropsychological Tests Corpus callosum Severity of Illness Index Corpus Callosum Temporal lobe 03 medical and health sciences 0302 clinical medicine Atrophy Neuroimaging Alzheimer Disease medicine Humans Dementia education Aged education.field_of_study Cambridge Neuropsychological Test Automated Battery Neuropsychology 030229 sport sciences medicine.disease Magnetic Resonance Imaging Sensory Systems Female Agenesis of Corpus Callosum Cognition Disorders Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Perceptual and Motor Skills. 92:1205-1210 |
| ISSN: | 1558-688X 0031-5125 |
| Popis: | task of the Attentional Set Shifting of the Cambridge Neuropsychological Test Automated Battery (CANTAB) and morphometry of the corpus callosum is examined in patients with Alzheimer's disease. Analysis showed patients with probable Alzheimer's disease are heterogeneous for the relationship between performances in the attentional test of the CANTAB and the anterior callosal atrophies. Interest in these results for clinical diagnosis of this mental disease is discussed. Alzheimer's dementia affects 0.3-3.2% of the population over the age of 65 years and 10.8% over the age of 80 years in Europe (31). This disease presents a main problem in our society. The final diagnosis of this disease is actually based on postmortem examination. Recent developments in Threedimensional Magnetic Resonance Lrnaging allow new work ul cerebral biometry. These techniques are powerful tools to study in vivo volumes and areas of brain and cerebral structures. A new field of research is focused on the study of relationships between atrophy of several cerebral structures and behavioral impairments in aging and dementia. These new techniques could provide a basis for diagnosis of Alzheimer's dsease not only on neuropsychological and behavioral impairments but also on specific cerebral atrophies. Particular interest has arisen in quantitative measures of the medial temporal lobe limbic structures because these areas are involved first and most severely by the neurofibrillary pathology of Alzheimer's disease (14). Neuroimaging studies provide evidence for significant atrophy of the hippocampus (2, 5, 8, 9, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 29, 36, 37). Damage |
| Databáze: | OpenAIRE |
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