The producing capabilities of Interferon-g and Interleukin-10 of spleen cells in primary and metastasized oral squamous cell carcinoma cells-implanted mice
| Autor: | Toshihiro Inagaki, Yasunori Muramatsu, Nobuo Kondoh, Harumi Kawaki, Yasuka Azuma, Eiichi Chihara, Eiji Takayama, Masako Mizuno-Kamiya |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
interleukin-10 Spleen lcsh:RC254-282 03 medical and health sciences spleen cells 0302 clinical medicine Interferon γ Interferon medicine Basal cell metastasized Lymph node business.industry Interleukin General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens oral squamous cell carcinoma Interleukin 10 030104 developmental biology medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis Cancer research Interferon-γ business medicine.drug |
| Zdroj: | Cancer Translational Medicine, Vol 3, Iss 6, Pp 194-199 (2017) |
| ISSN: | 2395-3977 |
| Popis: | Aim: The aim of this study is to compare the immunomodulatory effects exerted by primary versus metastasized oral squamous cell carcinoma (OSCC) cells. Methods: Mouse OSCC cell line Sq-1979, 233 cells established from implanted Sq-1979 cells, and L cells established from the metastasized lymph node tissues of Sq-1979-implanted mice were subcutaneously inoculated into the later abdominal area of syngeneic C3H mice. The producing capabilities of interferon (IFN)-γ, a Th1 cytokine, and interleukin (IL)-10, a Th2 cytokine, by anti-CD3 antibody-stimulated spleen cells were investigated in tumor bearing-mice. Results: The quantity of IFN-γ produced by stimulated spleen cells was significantly suppressed in the mice implanted with Sq-1979, 233, and L cells. Conversely, the production of IL-10 was significantly elevated in Sq-1979 and 233 cell-implanted mice while markedly suppressed in L cell-implanted mice. Conclusion: Our results suggest that the metastasized L cells have acquired differential immunomodulatory functions compared to the original Sq-1979 and primary 233 cells. |
| Databáze: | OpenAIRE |
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