Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division
| Autor: | Simon Hauri, Maxine V. Holder, Birgit L. Aerne, Matthias Gstaiger, Jennifer J Banerjee, Nicolas Tapon |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Frizzled animal structures Cell division QH301-705.5 Science Vesicular Transport Proteins planar cell polarity Biology asymmetric cell division General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Cell polarity Asymmetric cell division Animals Drosophila Proteins RASSF9/RASSF10 Biology (General) sensory organ precursor chemistry.chemical_classification D. melanogaster General Immunology and Microbiology Gene Expression Profiling General Neuroscience apical-basal polarity Cell Polarity Gene Expression Regulation Developmental General Medicine Bazooka/Par3 Dishevelled Cell biology Developmental Biology and Stem Cells 030104 developmental biology chemistry Medicine Drosophila Stem cell Developmental biology 030217 neurology & neurosurgery Drosophila Protein Research Article |
| Zdroj: | eLife, 6 eLife, Vol 6 (2017) eLife |
| ISSN: | 2050-084X |
| Popis: | Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery. eLife, 6 ISSN:2050-084X |
| Databáze: | OpenAIRE |
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