The northeast regional SPS meeting update: Safety pharmacology innovations and applications
| Autor: | Donald Hodges, Alfred W. Botchway, Martin Traebert, Tiffini Brabham, Malar Pannirselvam, Michael K. Pugsley |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Dual inhibition Societies Pharmaceutical BIA 10-2474 Drug Industry Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Drug Evaluation Preclinical Toxicology 030226 pharmacology & pharmacy Novel gene 03 medical and health sciences Presentation 0302 clinical medicine Inventions Medicine Animals Humans Drug industry media_common Pharmaceutical industry Pharmacology Medical education business.industry Safety pharmacology Congresses as Topic Clinical trial 030104 developmental biology business Neuroscience |
| Zdroj: | Journal of pharmacological and toxicological methods. 85 |
| ISSN: | 1873-488X |
| Popis: | The Safety Pharmacology Society (SPS) held a Northeast (NE) regional meeting in Boston, MA on May 13, 2016 at the Vertex Pharmaceuticals Incorporated site. There were 103 attendees from the pharmaceutical industry, contract research organizations (CROs), academia, and global regulatory agencies. An assortment of scientific topics were presented by 7 speakers that included broad topics in the cardiovascular (organ on chip, statistical power and translation of rat cardiovascular telemetry data and dual inhibition of IKr and IKs on QT interval prolongation) and central nervous system (in vitro platform for neurotoxicity, an integrated risk assessment of suicidal ideation and behavior, and EEG advances in safety pharmacology) and a novel topic discussing preclinical challenges faced in the development of a novel gene therapy. A highlight of the meeting was an in-depth discussion on the fatty acid acyl hydrolase (FAAH) inhibitor BIA 10-2474 which involved a comprehensive overview of the biology and pharmacology of FAAH followed by a presentation from the Biotrial (Rennes, France) team that conducted the clinical trial. An additional poster session was held that included 13 fascinating posters on cutting edge safety pharmacology topics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect