Acute Necrotizing Encephalopathy Associated With Parainfluenza Virus in a Caucasian Child
| Autor: | Eleni A. Vagiakou, Angeliki Skardoutsou, Dimitrios Gionnis, Sotiria Mastroyianni, Efstathia Katsarou, Panagiotis Mavromatis, Konstantinos A. Voudris |
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| Rok vydání: | 2003 |
| Předmět: |
Pediatrics
medicine.medical_specialty Pathology Disease White People 03 medical and health sciences 0302 clinical medicine Parainfluenza virus 030225 pediatrics medicine Humans Mild form Seroconversion Acute necrotizing encephalopathy Paramyxoviridae Infections business.industry Incidence (epidemiology) Clinical course Infant Prognosis Magnetic Resonance Imaging Pediatrics Perinatology and Child Health Female Neurology (clinical) Leigh Disease business 030217 neurology & neurosurgery Thalamic lesions |
| Zdroj: | Journal of Child Neurology. 18:570-572 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/08830738030180081301 |
| Popis: | Acute necrotizing encephalopathy is a severe parainfectious disorder with a clear racial predilection for Oriental children living in the Far East. The prognosis was originally reported as grave; however, a mild form of the disease has recently been described. A case of parainfluenza virus—associated acute necrotizing encephalopathy in a Caucasian child with a mild clinical course and excellent prognosis is presented. In this patient, the initial clinical picture was not very impressive, and the diagnosis was delayed until the third week of the illness, when neuroimaging was performed. Two months later, clinical and neuroimaging findings had almost completely resolved. Suggested criteria for a benign prognosis, such as normal liver function and cerebrospinal fluid protein levels, asymmetric thalamic lesions, and no brainstem involvement, were relevant in the present case. An extended diagnostic work-up for metabolic, vascular, coagulation, and infectious diseases was negative apart from a seroconversion for parainfluenza virus. To our knowledge, this is the first reported case of acute necrotizing encephalopathy associated with parainfluenza virus infection. Acute necrotizing encephalopathy, especially in the mild form, might not be fully recognized and could be underdiagnosed in Europe, where the reported incidence of the syndrome is very low. ( J Child Neurol 2003;18:570—572). |
| Databáze: | OpenAIRE |
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