TopicalPdb: A database of topically delivered peptides

Autor: Gursimran Bedi, Ankur Gautam, Ayesha Mehta, Charu Sood, Deepika Mathur, Gajendra P. S. Raghava, Priyanka Firmal
Rok vydání: 2018
Předmět:
0301 basic medicine
Multiple Alignment Calculation
Bioinformatics
Computer science
Administration
Topical
Sequence Databases
lcsh:Medicine
Sequence alignment
Peptide
Nose
Research and Analysis Methods
computer.software_genre
030226 pharmacology & pharmacy
Database and Informatics Methods
03 medical and health sciences
0302 clinical medicine
Ocular System
Computational Techniques
Medicine and Health Sciences
Database Searching
Databases
Protein
Sequence Similarity Searching
lcsh:Science
Routes of Administration
Pharmacology
chemistry.chemical_classification
Multidisciplinary
Database
lcsh:R
Biology and Life Sciences
Split-Decomposition Method
Biological Databases
030104 developmental biology
chemistry
Face
Eyes
lcsh:Q
Anatomy
Peptides
Sequence Analysis
Sequence Alignment
Head
computer
Research Article
Zdroj: PLoS ONE, Vol 13, Iss 2, p e0190134 (2018)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0190134
Popis: TopicalPdb (http://crdd.osdd.net/raghava/topicalpdb/) is a repository of experimentally verified topically delivered peptides. Data was manually collected from research articles. The current release of TopicalPdb consists of 657 entries, which includes peptides delivered through the skin (462 entries), eye (173 entries), and nose (22 entries). Each entry provides comprehensive information related to these peptides like the source of origin, nature of peptide, length, N- and C-terminal modifications, mechanism of penetration, type of assays, cargo and biological properties of peptides, etc. In addition to natural peptides, TopicalPdb contains information of peptides having non-natural, chemically modified residues and D-amino acids. Besides this primary information, TopicalPdb stores predicted tertiary structures as well as peptide sequences in SMILE format. Tertiary structures of peptides were predicted using state-of-art method PEPstrMod. In order to assist users, a number of web-based tools have been integrated that includes keyword search, data browsing, similarity search and structural similarity. We believe that TopicalPdb is a unique database of its kind and it will be very useful in designing peptides for non-invasive topical delivery.
Databáze: OpenAIRE
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