Lymphoma-specific T- and B-cell responses suggest the involvement of HTLV-I in virus-non-productive lymphomas of a married couple
| Autor: | Schlote W, Mann Dl, E M Schneider, Peter Wernet, Josef Schneider, Saal Jg, Graham Pawelec |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Cancer Research T-Lymphocytes Biology Antibodies Viral Lymphocyte Activation Virus Immune system HLA Antigens medicine Cytotoxic T cell Humans B cell Aged B-Lymphocytes Lymphokine-activated killer cell Deltaretrovirus Antibodies Lymphoma Non-Hodgkin T lymphocyte HLA-DR Antigens medicine.disease HTLV-I Infections Lymphoma medicine.anatomical_structure Phenotype Oncology Immunology Female Clone (B-cell biology) |
| Zdroj: | International journal of cancer. 41(4) |
| ISSN: | 0020-7136 |
| Popis: | The occurrence of aberrant cellular progeny is not an infrequent event in vivo. Viral infections (Hanto et al., 1981; Gallo, 1984) and/or failures in genetic programming during cell proliferarion may facilitate the manifestation of malignancy in states of incomplete immune surveillance. This is suggested by a high incidence of lymphoid malignancies in immunode-pressed individuals, as for example after organ transplantation (Penn, 1981). Efficient cellular defense mechanisms which control malignant growth have been postulated. So far, MHC-restricted, tumor-specific cytotoxic T cells have not been identified in vivo. Moreover, effector cells with natural killer activity have not consistently been shown to function as general or specific anti-tumor agents in vivo. Nevertheless, LAK cells are presently under investigation in adoptive immuno-therapy for tumors. The concept of LAK-cell treatment is based on the observation that high concentrations of interleu-kin 2 (IL-2) induce activation and proliferation of autologous, tumor-specific cytotoxic cells (Hersey et al., 1981; Lotze et al., 1981). The most promising results have been obtained in mouse tumor models, whereas treatment of human diseases has rarely been successful (Rosenberg et al., 1986). In the present report, high percentages of CD25-positive T lymphocytes were detected in PB and LN cell suspensions of a patient with a B-cell NHL. These T cells were successfully enriched in cultures containing low doses of IL-2. The CTX mediated by these T-cell lines and a single T-cell clone derived from them was specific for autologous lymphoma cells as well as for the lymphoma cells from a different individual. Interestingly, an HTLV-I-infected tumor-cell line was recognized also. The specific cellular as well as the humoral immune response. however, was drastically reduced following chemo- and radiotherapy. In contrast, non-specific CTX mediated by aclivated NK-like cells persisted. |
| Databáze: | OpenAIRE |
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