Special features of the DNA-hydrolyzing activity of the antibodies in systemic lupus erythematosus
| Autor: | D. A. Temnikov, V. G. Vinter, T. A. Nevzorova |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Temperature resistance
Anti-nuclear antibody Ph optimum Biochemistry chemistry.chemical_compound Blood serum Bioorganic chemistry Humans Lupus Erythematosus Systemic Deoxyribonucleases biology Hydrolysis Temperature DNase activity General Medicine DNA Hydrogen-Ion Concentration Molecular biology Kinetics Spectrometry Fluorescence chemistry Antibodies Antinuclear Immunoglobulin G biology.protein Antibody Plasmids |
| Zdroj: | Biochemistry. Biokhimiia. 68(12) |
| ISSN: | 0006-2979 |
| Popis: | Two types of IgG anti-DNA antibodies exhibiting DNA-hydrolyzing activity have been isolated from blood serum of patients with systemic lupus erythematosus. This DNase activity of antibodies differs from serum DNases by the non-processive mode, temperature resistance, pH optimum, and the rate of DNA hydrolysis. It is suggested that the anti-DNA antibody molecule possessing DNase activity contains two sites: one site determines specificity of antibody-DNA interaction, whereas the other is responsible for manifestation of the catalytic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink