Ion dynamics in a trapped ion mobility spectrometer
| Autor: | Mark E. Ridgeway, Melvin A. Park, John Daniel DeBord, Francisco Fernandez-Lima, Diana R. Hernandez, Desmond Allen Kaplan |
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| Rok vydání: | 2014 |
| Předmět: |
Ions
Electrical mobility Resolution (mass spectrometry) Chemistry Ion-mobility spectrometry Spectrum Analysis Dynamics (mechanics) Analytical chemistry Biochemistry Article Analytical Chemistry Ion Amplitude Electric field Calibration Electrochemistry Environmental Chemistry Atomic physics Spectroscopy |
| Zdroj: | The Analyst. 139:1913-1921 |
| ISSN: | 1364-5528 0003-2654 |
| Popis: | In the present paper, theoretical simulations and experimental observations are used to describe the ion dynamics in a trapped ion mobility spectrometer. In particular, the ion motion, ion transmission and mobility separation are discussed as a function of the bath gas velocity, radial confinement, analysis time and speed. Mobility analysis and calibration procedure are reported for the case of sphere-like molecules for positive and negative ion modes. Results showed that a maximal mobility resolution can be achieved by optimizing the gas velocity, radial confinement (RF amplitude) and ramp speed (voltage range and ramp time). The mobility resolution scales with the electric field and gas velocity and R = 100-250 can be routinely obtained at room temperature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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