Saccharomyces boulardii fungemia caused by treatment with a probioticum
| Autor: | Henning Glerup, Julie Bjerre Thygesen, Britta Tarp |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents medicine.medical_treatment Gastroenterology Article Saccharomyces Amphotericin B Internal medicine medicine Humans Intensive care medicine Enterocolitis Pseudomembranous Fungemia Aged Enterocolitis biology business.industry Probiotics General Medicine Bowel resection Clostridium difficile biology.organism_classification medicine.disease Metronidazole Vancomycin Female medicine.symptom business Saccharomyces boulardii medicine.drug |
| Zdroj: | Thygesen, J B, Glerup, H & Tarp, B 2012, ' Saccharomyces boulardii fungemia caused by treatment with a probioticum ', B M J Case Reports, vol. 2012 . https://doi.org/10.1136/bcr.06.2011.4412 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr.06.2011.4412 |
| Popis: | Saccharomyces cerevisiae, known as baker's yeast, is normally considered a non-pathogenic yeast. A genetically very similar subtype, S boulardii, is used in a probioticum (Sacchaflor) to prevent antibiotic-associated diarrhoea and in the treatment of recurrent Clostridium difficile associated diarrhoea. The authors present a case report of a 79-year-old woman with rheumatoid arthritis, who after a bowel resection developed S boulardii fungemia. Her postoperative course was complicated by nutritional problems, anaemia and several nosocomial infections including recurrent C difficile associated diarrhoea. The diarrhoea was treated with metronidazole, vancomycin and Sacchaflor. After 13 days of treatment, the patient developed fungemia with S boulardii. Treatment with Sacchaflor was immediately discontinued and the patient was successfully treated with amphotericin B. Fungemia is a rare, but a serious complication to treatment with probiotics. Accordingly, the authors find it important to remind the clinicians of this risk when prescribing probiotics especially to immunocompromised patients. |
| Databáze: | OpenAIRE |
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