The contryphans, a d-trvptophan-containing family of Conus peptides: interconversion between conformers
| Autor: | Michelle Grilley, David R. Hillyard, Maren Watkins, Lourdes J. Cruz, Elsie C. Jimenez, Baldomero M. Olivera, Richard B. Jacobsen |
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| Rok vydání: | 2009 |
| Předmět: |
DNA
Complementary animal structures Conus radiatus Protein Conformation Stereochemistry Molecular Sequence Data Mollusk Venoms Venom Peptide Peptides Cyclic Polymerase Chain Reaction complex mixtures Biochemistry Conus purpurascens Endocrinology Protein structure Conus Animals Amino Acid Sequence Peptide sequence Chromatography High Pressure Liquid chemistry.chemical_classification Contryphan Base Sequence biology biology.organism_classification Recombinant Proteins chemistry Mollusca |
| Zdroj: | The Journal of Peptide Research. 51:173-179 |
| ISSN: | 1397-002X |
| DOI: | 10.1111/j.1399-3011.1998.tb01213.x |
| Popis: | We previously characterized contryphan-R, a D-tryptophan-containing octapeptide from the venom of Conus radiatus. In this study, we present evidence that the contryphan family of peptides is widely distributed in venoms of the fish-hunting cone snails. We purified, synthesized and characterized contryphan-Sm from Conus stercusmuscarum venom, and obtained molecular evidence for the existence of a third peptide, contryphan-P from Conus purpurascens venom ducts. The sequences of these three contryphans showed identity in seven of eight amino acids and a conserved pattern of post-translational modification. We also demonstrate that contryphan-Sm equilibrates between two distinct conformational states. |
| Databáze: | OpenAIRE |
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