Biological Activity of Selected Natural and Synthetic Terpenoid Lactones
| Autor: | Lucyna Balcerzak, Stanisław Lochyński, Daniel Strub, Alicja K. Surowiak |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Stereochemistry Anti-Inflammatory Agents Antineoplastic Agents biological activity Review 01 natural sciences Chemical synthesis Catalysis lactones Inorganic Chemistry Antimalarials medicine Humans Moiety Biology (General) Physical and Theoretical Chemistry Artemisinin QD1-999 Molecular Biology Spectroscopy chemistry.chemical_classification Plant Extracts Terpenes 010405 organic chemistry Chemistry fungi Organic Chemistry Biological activity General Medicine Antimicrobial Artemisinins Terpenoid 0104 chemical sciences Computer Science Applications 010404 medicinal & biomolecular chemistry Sesquiterpenes terpenoid Lactone medicine.drug |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5036, p 5036 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22095036 |
| Popis: | Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by chemical synthesis. Terpenoids possessing lactone moieties are known for their cytotoxic, anti-inflammatory, antimicrobial, anticancer, and antimalarial activities. Moreover, one terpenoid lactone, artemisinin, is used as a drug against malaria. Because of these abilities, there is constant interest in new terpenoid lactones that are both isolated and synthesized, and their biological activities have been verified. In some cases, the activity of the terpenoid lactone is specifically connected to the lactone moiety. Recent works have revealed that new terpenoid lactones can demonstrate such functions and are thus considered to be potential active agents against many diseases. |
| Databáze: | OpenAIRE |
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