Function and specificity of Hox genes
| Autor: | Luis F. de Navas, David Foronda, Daniel L. Garaulet, Ernesto Sánchez-Herrero |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Ministerio de Educación (España), Fundación Ramón Areces, Ministerio de Educación y Ciencia (España), European Commission |
| Rok vydání: | 2009 |
| Předmět: |
Embryology
animal structures Organogenesis Gene regulatory network Apoptosis Computational biology Signalling Biology Models Biological Gene cluster Animals Hox gene Gene Transcription factor Body Patterning Cell Proliferation Genetics Regulation of gene expression Homeodomain Proteins Gene Expression Regulation Developmental Downstream gene Hox engrailed Multigene Family embryonic structures Homeobox Networks Developmental Biology Signal Transduction |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The Hox genes specify different structures along the anteroposterior axis of bilaterians. They code for transcription factors including a conserved domain, the homeodomain, that binds DNA. The specificity of Hox function is determined by each gene controlling the expression of different groups of downstream genes. These can be other transcription factors, elements in signaling pathways or realizator genes that carry out basic cellular functions. In regulating specific targets, the Hox genes interact with members of signaling pathways and with other proteins, thus forming part of gene networks that contribute to the modification of homologous structures or to the creation of new organs. This work has been supported by grants from the Dirección General de Investigación Científica y Técnica (N° BFU2005-04342), the Consolider Programme from the Ministerio de Educación and from an Institutional Grant from the Fundación Ramón Areces. D. F. is supported by a fellowship from the Spanish Ministerio de Educación y Ciencia and D. L. G. by a I3P fellowship from the C.S.I.C. co-financed by the European Social Fund. |
| Databáze: | OpenAIRE |
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