Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma
Autor: | Jing Quan, Xiang Pan, Yongqing Lai, Shangqi Yang, Yun Chen, Xiangming Mao, Jia Hu, Lu Jin, Yifan Li, Yaoting Gui, Tao He |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male 0301 basic medicine Cancer Research Pathology medicine.medical_specialty Cell Apoptosis Biology urologic and male genital diseases medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Renal cell carcinoma Cell Line Tumor Biomarkers Tumor Genetics medicine Humans Carcinoma Renal Cell neoplasms Molecular Biology Aged Cell Proliferation Base Sequence Oncogene Cancer Middle Aged Cell cycle medicine.disease Molecular medicine Kidney Neoplasms female genital diseases and pregnancy complications Up-Regulation MicroRNAs 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Molecular Medicine Female RNA Long Noncoding Carcinogenesis Sequence Alignment |
Zdroj: | Molecular Medicine Reports. 16:7072-7079 |
ISSN: | 1791-3004 1791-2997 |
Popis: | Renal cell carcinoma (RCC) is the most common type of kidney cancer and the prognosis of metastatic RCC remains poor, with a high rate of recurrence and mortality. Long non‑coding RNA (lncRNA) is a class of RNA which serves important roles in multiple cellular processes and tumorigenesis. In the present study, the expression and function of lncRNA eosinophil granule ontogeny transcript (EGOT) were examined in RCC. In 24 paired tissues (RCC tissues and adjacent normal tissues) the results of reverse transcription‑quantitative polymerase chain reaction analysis revealed that EGOT was downregulated in 22 RCC tissues compared with paired tissues. Upregulation of lncRNA EGOT by transfection of 786‑O and ACHN RCC cells with pcDNA3.1‑EGOT suppressed cell proliferation, migration and invasion, and induced RCC cell apoptosis. The results demonstrated that EGOT may serve as a tumor suppressor in RCC and may be a potential prognostic biomarker of RCC. |
Databáze: | OpenAIRE |
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