Identification of lncRNA EGOT as a tumor suppressor in renal cell carcinoma

Autor: Jing Quan, Xiang Pan, Yongqing Lai, Shangqi Yang, Yun Chen, Xiangming Mao, Jia Hu, Lu Jin, Yifan Li, Yaoting Gui, Tao He
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
Cell
Apoptosis
Biology
urologic and male genital diseases
medicine.disease_cause
Biochemistry
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Cell Movement
Renal cell carcinoma
Cell Line
Tumor
Biomarkers
Tumor
Genetics
medicine
Humans
Carcinoma
Renal Cell
neoplasms
Molecular Biology
Aged
Cell Proliferation
Base Sequence
Oncogene
Cancer
Middle Aged
Cell cycle
medicine.disease
Molecular medicine
Kidney Neoplasms
female genital diseases and pregnancy complications
Up-Regulation
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Female
RNA
Long Noncoding
Carcinogenesis
Sequence Alignment
Zdroj: Molecular Medicine Reports. 16:7072-7079
ISSN: 1791-3004
1791-2997
Popis: Renal cell carcinoma (RCC) is the most common type of kidney cancer and the prognosis of metastatic RCC remains poor, with a high rate of recurrence and mortality. Long non‑coding RNA (lncRNA) is a class of RNA which serves important roles in multiple cellular processes and tumorigenesis. In the present study, the expression and function of lncRNA eosinophil granule ontogeny transcript (EGOT) were examined in RCC. In 24 paired tissues (RCC tissues and adjacent normal tissues) the results of reverse transcription‑quantitative polymerase chain reaction analysis revealed that EGOT was downregulated in 22 RCC tissues compared with paired tissues. Upregulation of lncRNA EGOT by transfection of 786‑O and ACHN RCC cells with pcDNA3.1‑EGOT suppressed cell proliferation, migration and invasion, and induced RCC cell apoptosis. The results demonstrated that EGOT may serve as a tumor suppressor in RCC and may be a potential prognostic biomarker of RCC.
Databáze: OpenAIRE
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