Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes

Autor: Mary Byrn, Patricia B. Mumby, William Adams, Sue Penckofer, Diane E. Wallis, Joanne Kouba, Mary Ann Emanuele
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
medicine.medical_specialty
Time Factors
Article Subject
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
Anxiety
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Proof of Concept Study
vitamin D deficiency
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Surveys and Questionnaires
medicine
Vitamin D and neurology
Humans
030212 general & internal medicine
Vitamin D
Depression (differential diagnoses)
2. Zero hunger
Glycated Hemoglobin
lcsh:RC648-665
business.industry
Depression
Middle Aged
medicine.disease
Vitamin D Deficiency
3. Good health
Patient Health Questionnaire
Affect
Mood
Mental Health
Treatment Outcome
Diabetes Mellitus
Type 2
Dietary Supplements
Ergocalciferols
Physical therapy
Clinical Study
Female
medicine.symptom
business
Body mass index
Biomarkers
Zdroj: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2017 (2017)
ISSN: 2314-6745
DOI: 10.1155/2017/8232863
Popis: Objective. The aim of this study was to determine the effect of vitamin D supplementation on improving mood (depression and anxiety) and health status (mental and physical) in women with type 2 diabetes mellitus (T2DM). Methods. Fifty women with T2DM and significant depressive symptomology were enrolled into the “Sunshine Study,” where weekly vitamin D supplementation (ergocalciferol, 50,000 IU) was given to all participants for six months. The main outcomes included (1) depression (Center for Epidemiologic Studies Depression, CES-D, and Patient Health Questionnaire, PHQ-9), (2) anxiety (State-Trait Anxiety), and (3) health status (Short Form, SF-12). Results. Forty-six women (92%) completed all visits. There was a significant decrease in depression (CES-D and PHQ-9, p<0.001) and anxiety (state and trait, p<0.001). An improvement in mental health status (SF-12, p<0.001) was also found. After controlling for covariates (race, season of enrollment, baseline vitamin D, baseline depression (PHQ-9), and body mass index), the decline in depression remained significant (CES-D, p<0.001). There was a trend for a better response to supplementation for women who were not taking medications for mood (antidepressants or anxiolytics) (p=0.07). Conclusions. Randomized trials to confirm that vitamin D supplementation can improve mood and health status in T2DM women are needed.
Databáze: OpenAIRE
Externí odkaz: