Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients
| Autor: | Tulio C. Lins, Marcus de Melo Teixeira, Izabel Cristina Rodrigues da Silva, Maria Heloisa Souza Lima Blotta, Anamélia Lorenzetti Bocca, Maria Sueli Soares Felipe, Rinaldo Wellerson Pereira, Alfredo M. Goes, Rodrigo G. Vieira, Viviane Furlan Lozano |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Microbiology (medical) haplotypes lcsh:Arctic medicine. Tropical medicine Adolescent Genotype lcsh:RC955-962 T cell Population lcsh:QR1-502 Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide lcsh:Microbiology Young Adult Gene Frequency Brazilian population Antigens CD single nucleotide polymorphism Fungos patogênicos medicine Humans CTLA-4 Antigen Genetic Predisposition to Disease Allele education Aged Paracoccidioides brasiliensis Genetics education.field_of_study Paracoccidioidomycosis Haplotype Middle Aged Paracoccidioidomicose biology.organism_classification medicine.disease medicine.anatomical_structure Case-Control Studies PCM Chronic Disease Immunology admixture Female |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 106, Iss 2, Pp 220-226 (2011) Memórias do Instituto Oswaldo Cruz, Volume: 106, Issue: 2, Pages: 220-226, Published: MAR 2011 Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| ISSN: | 1678-8060 |
| Popis: | The CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1 and paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. For this purpose, 66 chronic form PCM patients and 76 healthy controls had their allele, genotype and haplotype frequencies determined. The genetic admixture structure of the patients and controls was evaluated to eliminate ancestral bias. The comparison of frequencies indicated no significant differences between patients and controls that could link the SNPs to PCM. Groups were admixture matched with no difference observed in population ancestry inference, indicating that the absence of association between CTLA-4 polymorphisms and PCM could not be attributed to ancestral bias. This study showed that there was no association between the CTLA-4 SNPs -318 and +49 and the resistance or susceptibility to PCM. |
| Databáze: | OpenAIRE |
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