Depression, social support, and beta-adrenergic transcription control in human ovarian cancer
| Autor: | Anil K. Sood, Michael J. Goodheart, Caroline Y. Sung, David M. Lubaroff, Donna M. Farley, Frank J. Penedo, Susan K. Lutgendorf, Jesusa M.G. Arevalo, Koen DeGeest, Steve W. Cole, Joseph A. Lucci |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Transcription Genetic Immunology Activating transcription factor Biology CREB Article Behavioral Neuroscience Norepinephrine Mediator Risk Factors Internal medicine Neoplasms medicine Humans Cyclic AMP Response Element-Binding Protein Transcription factor Chromatography High Pressure Liquid Aged Oligonucleotide Array Sequence Analysis Regulation of gene expression Aged 80 and over Ovarian Neoplasms Endocrine and Autonomic Systems Depression Reverse Transcriptase Polymerase Chain Reaction NF-kappa B Social Support Middle Aged medicine.disease Activating Transcription Factors Gene Expression Regulation Neoplastic Endocrinology Cancer research biology.protein Female Social genomics Signal transduction Ovarian cancer |
| Zdroj: | Brain, behavior, and immunity. 23(2) |
| ISSN: | 1090-2139 |
| Popis: | Motivated by previous indications that beta-adrenergic signaling can regulate tumor cell gene expression in model systems, we sought to determine whether similar dynamics occur in primary human ovarian cancer. DNA microarray analyses of 10 ovarian carcinomas identified 266 human transcripts that were differentially expressed in tumors from patients with elevated biobehavioral risk factors (high depressive symptoms and low social support) relative to grade- and stage-matched tumors from low-risk patients. Promoter-based bioinformatic analyses indicated increased activity of several beta-adrenergically-linked transcription control pathways, including CREB/ATF, NF-kappaB/Rel, STAT, and Ets family transcription factors. Consistent with increased beta-adrenergic signaling, high biobehavioral risk patients also showed increased intra-tumor concentrations of norepinephrine (but no difference in plasma norepinephrine). These data show that genome-wide transcriptional profiles are significantly altered in tumors from patients with high behavioral risk profiles, and they identify beta-adrenergic signal transduction as a likely mediator of those effects. |
| Databáze: | OpenAIRE |
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