Free propagation phase-contrast breast CT provides higher image quality than cone-beam breast-CT at low radiation doses: a feasibility study on human mastectomies
| Autor: | Susanne Wienbeck, Fulvia Arfelli, Timur E. Gureyev, Diego Dreossi, Maura Tonutti, Sarah J. Lewis, Patrycja Baran, Patrick C. Brennan, Jonas Albers, Giuliana Tromba, Ya. I. Nesterets, Christina Perske, Konstantin Mikhailovitch Pavlov, S. C. Mayo, U. Fischer, S. Tavakoli Taba, Serena Pacilè, Christian Dullin, Anton Maksimenko |
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| Přispěvatelé: | Pacile, S., Dullin, C., Baran, P., Tonutti, M., Perske, C., Fischer, U., Albers, J., Arfelli, F., Dreossi, D., Pavlov, K., Maksimenko, A., Mayo, S. C., Nesterets, Y. I., Taba, S. T., Lewis, S., Brennan, P. C., Gureyev, T. E., Tromba, G., Wienbeck, S. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cone beam computed tomography
Image quality medicine.medical_treatment Phase contrast microscopy lcsh:Medicine Breast Neoplasms Imaging techniques Radiation Radiation Dosage Article 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences x-ray phase contrast 0302 clinical medicine Breast cancer law Medicine Humans Breast lcsh:Science Computed tomography Mastectomy Breast ct CT (PB-CT ) Multidisciplinary business.industry synchrotron radiation Phantoms Imaging breast imaging lcsh:R Cone-Beam Computed Tomography medicine.disease 3. Good health Tomography x ray computed Computed tomography x-ray phase contrast synchrotron radiation breast imaging 030220 oncology & carcinogenesis Feasibility Studies lcsh:Q Cancer imaging Female business Nuclear medicine Tomography X-Ray Computed Biological physics Synchrotrons |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) |
| Popis: | In this study we demonstrate the first direct comparison between synchrotron x-ray propagation-based CT (PB-CT) and cone-beam breast-CT (CB-CT) on human mastectomy specimens (N = 12) including different benign and malignant lesions. The image quality and diagnostic power of the obtained data sets were compared and judged by two independent expert radiologists. Two cases are presented in detail in this paper including a comparison with the corresponding histological evaluation. Results indicate that with PB-CT it is possible to increase the level of contrast-to-noise ratio (CNR) keeping the same level of dose used for the CB-CT or achieve the same level of CNR reached by CB-CT at a lower level of dose. In other words, PB-CT can achieve a higher diagnostic potential compared to the commercial breast-CT system while also delivering a considerably lower mean glandular dose. Therefore, we believe that PB-CT technique, if translated to a clinical setting, could have a significant impact in improving breast cancer diagnosis. |
| Databáze: | OpenAIRE |
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