Interleukin-2 receptor expression in peripheral blood lymphocytes from systemic lupus erythematosus patients: relationship to clinical activity
| Autor: | Delbert R. Wigfall, Stanley C. Jordan, Daniel J. Wallace, Rebecca Sakai |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Interleukin 2
medicine.medical_specialty Lymphocyte Receptor expression Immunology Biology Pathology and Forensic Medicine Cell surface receptor Internal medicine medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Lymphocytes Phytohemagglutinins Receptors Immunologic skin and connective tissue diseases Receptor Lupus erythematosus Lymphokine Receptors Interleukin-2 medicine.disease medicine.anatomical_structure Endocrinology Immunoglobulin G Antibody Formation biology.protein Interleukin-2 Antibody medicine.drug |
| Zdroj: | Clinical immunology and immunopathology. 47(3) |
| ISSN: | 0090-1229 |
| Popis: | Deficient interleukin-2 (IL-2) production and other T-cell dysfunctions have been demonstrated in active systemic lupus erythematosus (SLE). The generation of IL-2 receptors is known to be important to the growth and differentiation of T and B lymphocytes. This study investigated IL-2 receptor expression in peripheral blood lymphocytes (PBL) from patients with active and inactive SLE. PBL from 27 SLE patients, diagnosed by revised ARA criteria, were assayed for IL-2 receptor expression, IL-2 and immunoglobulin (Ig) production. PBL from SLE patients with active disease spontaneously expressed increased numbers of IL-2 receptors compared to those with inactive disease (P less than 0.01) and normal donors (P less than 0.01). There was no significant increase in IL-2 receptors expression in PBL from active SLE patients in response to mitogenic stimulation with PHA compared to inactive SLE patients and normal donors. There was negligible IL-2 production in response to mitogenic stimulation and increased spontaneous IgG production by PBL from active SLE patients compared to normal donors (P less than 0.001). Purified B cells isolated from active SLE patients showed significant spontaneous IL-2 receptor expression when compared to spontaneous IL-2 receptor expression by normal B cells (P = 0.005). Therefore, in addition to derangements in Ig and IL-2 production, the level of spontaneous expression of IL-2 receptors may represent a cellular indicator of disease activity, and hence, may be a useful parameter in monitoring disease activity in SLE patients. The significance of the increased IL-2 receptor expression on B cells of active SLE patients is unknown, but may represent a marker of polyclonal activation of these cells. |
| Databáze: | OpenAIRE |
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