Effects of organic acids on stria vascularis ultrastructure and function in the chinchilla
| Autor: | Craig Whitworth, Vernedra Scott, Leonard P. Rybak, Aruna D. Weberg |
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| Rok vydání: | 1992 |
| Předmět: |
Chinchilla
medicine.medical_specialty Endocochlear potential Sodium Salicylate chemistry.chemical_compound Furosemide Internal medicine biology.animal Edema otorhinolaryngologic diseases medicine Animals Sodium salicylate biology business.industry Probenecid Stria Vascularis Penicillin G General Medicine Anatomy Penicillin Microscopy Electron Endocrinology Otorhinolaryngology chemistry Injections Intravenous Cochlear Microphonic Potentials sense organs medicine.symptom business Salicylic acid medicine.drug |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 249(3) |
| ISSN: | 0937-4477 |
| Popis: | The purpose of this study was to compare the effects of several organic acids (probenecid, sodium salicylate and penicillin G) on the endocochlear potential (EP) and the ultrastructure of the stria vascularis of the chinchilla with the effects of furosemide on these parameters. chinchillas received 50 mg/kg i.v. doses of probenecid, sodium salicylate or penicillin G, or 25 mg/kg i.v. furosemide. The EP was monitored continuously before and for 60 min afterwards. The stria vascularis was removed at 10-min intervals from animals and from 10 to 60 min after the injection of these agents. Specimens were then processed for transmission electron microscopy. Only furosemide had an effect on the EP, causing a reversible reduction. The reduction of the EP was accompanied by the appearance of edema in the intercellular spaces of the stria vascularis. No significant edema was found after probenecid, sodium salicylate or penicillin G. This was consistent with the finding that none of these latter three agents affected the endocochlear potential. |
| Databáze: | OpenAIRE |
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