APOE-MS4A genetic interactions are associated with executive dysfunction and network abnormality in clinically mild Alzheimer's disease

Autor: Chi-Wei Huang, Etsuro Mori, Chiung-Chih Chang, Maki Suzuki, Ya-Ting Chang, Manabu Ikeda, Jun-Jun Lee, Wen-Neng Chang
Rok vydání: 2018
Předmět:
Apolipoprotein E
Male
TMB
Trail Making Test B
Executive control network
NCs
normal controls
Disease
MS4A
Bioinformatics
MMSE
Mini-Mental State Examination
lcsh:RC346-429
NFTs
neurofibrillary tangles
Pathogenesis
Executive Function
0302 clinical medicine
Neural Pathways
TIV
total intracranial volume
Medicine
rs-fMRI
resting state-functional MRI
ANOVA
analysis of variance
Brain Mapping
ε4+/T-allele-carriers
APOE-ε4 carriers with MS4A-rs670139-T-allele genotype
ε4 non-carriers
APOE-ε4 non-carriers
Genetic interaction
05 social sciences
HWE
Hardy-Weinberg equilibrium
OFI
orbital frontoinsular
Brain
Cognition
Calculation
Magnetic Resonance Imaging
DSB
Digit Span Backward
Neurology
DLPFC
dorsolateral prefrontal cortex
lcsh:R858-859.7
Female
AD
Alzheimer's disease
Abnormality
APOE
Aβ
amyloid β
FDR
false discovery rate
Cognitive Neuroscience
MNI
Montreal Neurological Institute
FC
functional connectivity
Single-nucleotide polymorphism
lcsh:Computer applications to medicine. Medical informatics
CVVLT
Chinese Version Verbal Learning Test
Polymorphism
Single Nucleotide
050105 experimental psychology
Article
03 medical and health sciences
Apolipoproteins E
Alzheimer Disease
SPM 12
Statistic Parametric Mapping software version 12
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
ε4+ carriers
APOE-ε4 carriers
ε4−/T-allele-carriers
APOE-ε4 non-carriers with MS4A-rs670139-T-allele genotype
lcsh:Neurology. Diseases of the nervous system
Aged
business.industry
apoE
apolipoprotein E
GM
grey matter
Antigens
CD20
ECN
executive control network
ε4−/GG-carriers
APOE-ε4 non-carriers with MS4A-rs670139-GG genotype
PCC
posterior cingulate cortex
DMN
default mode network
CDR
Clinical Dementia Rating
Neurology (clinical)
business
MRI
magnetic resonance imaging
030217 neurology & neurosurgery
Executive dysfunction
ε4+/GG-carriers
APOE-ε4 carriers with MS4A-rs670139-GG genotype
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 21, Iss, Pp-(2019)
ISSN: 2213-1582
Popis: Purpose of the research Although single nucleotide polymorphisms of membrane-spanning 4A (MS4A) (rs670139) and several other susceptibility genes have shown interaction effects on the risk of Alzheimer's disease (AD), little is known about the interaction effects of apolipoprotein E (APOE) with MS4A (rs670139) on cognitive performances, and the underlying pathogenesis is unclear. The study aimed to investigate the APOE-MS4A (rs670139) interaction effects on cognitive performances, cortical volumes, and functional connectivity (FC) in brain networks. Principal results Cognitive performances were characterized in each genotypic group, and were compared between normal controls and patients in each genotypic group. APOE-MS4A interaction effects on memory and executive function scores, cortical volumes, and FC in brain networks were demonstrated. Significant effects of APOE-MS4A interactions on FC were observed in executive control network (ECN) (T maxima = 4.99, false discovery rate-corrected p
Highlights • APOE-MS4A interactions affect executive control network (ECN) and calculation score. • Calculation score is correlated with functional connectivity in ECN. • Variation in ECN is associated with genetic effects on calculation performances. • The calculation score is correlated with each frontal volume. • Genotypic variation affects the relationship between calculation and frontal volume.
Databáze: OpenAIRE
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