Hydrogen therapy as an effective and novel adjuvant treatment against COVID-19
| Autor: | Wei-Peng Li, Jian-Hui Peng, Jishun Yang, Deng-Yong Hou, Ju-Fen Hui, Ming-Ke Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 2019-20 coronavirus outbreak Time Factors Coronavirus disease 2019 (COVID-19) medicine.medical_treatment Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) MEDLINE Letter to Editor Young Adult Pulmonary Disease Chronic Obstructive Correspondence Administration Inhalation medicine Humans Prospective Studies Aged Inflammation SARS-CoV-2 business.industry COVID-19 General Medicine Middle Aged Virology Asthma Breath Tests Cytokines Female Gases AcademicSubjects/MED00010 business Adjuvant Hydrogen |
| Zdroj: | QJM: An International Journal of Medicine |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcaa301 |
| Popis: | Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases.We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD).Prospective study.In total, 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45 min in 10 patients with asthma and 10 patients with COPD. The levels of granulocyte-macrophage colony stimulating factor, interferon-γ, interleukin-1β (IL-1β), IL-2, IL-4, IL-6 and so on in peripheral blood and exhaled breath condensate (EBC) before and after 'XEN' inhalation were measured.45 minutes 'XEN' inhalation once decreased monocyte chemotactic protein 1 level in both COPD (564.70-451.51 pg/mL, P = 0.019) and asthma (386.39-332.76 pg/mL, P = 0.033) group, while decreased IL-8 level only in asthma group (5.25-4.49 pg/mL, P = 0.023). The level of EBC soluble cluster of differentiation-40 ligand in COPD group increased after inhalation (1.07-1.16 pg/mL, P = 0.031), while IL-4 and IL-6 levels in EBC were significantly lower after inhalation in the COPD (0.80-0.64 pg/mL, P = 0.025) and asthma (0.06-0.05 pg/mL, P = 0.007) group, respectively.A single inhalation of hydrogen for 45 min attenuated inflammatory status in airways in patients with asthma and COPD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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