Gas6 gene rs8191974 and Ap3s2 gene rs2028299 are associated with type 2 diabetes in the northern Chinese Han population
| Autor: | Elena V Kazakova, Tianwei Zghuang, Tingting Li, Hong Qiao, Qingxiao Fang, Jun Han |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine China medicine.medical_specialty Genotype Single-nucleotide polymorphism Type 2 diabetes Biology Logistic regression Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Asian People Internal medicine medicine Humans SNP Genetic Predisposition to Disease Allele Gene Alleles Genetic Association Studies Genetics Type 2 Diabetes Mellitus medicine.disease 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Intercellular Signaling Peptides and Proteins Female |
| Zdroj: | Acta Biochimica Polonica. 64 |
| ISSN: | 1734-154X 0001-527X |
| Popis: | Previous studies in other countries have shown that single nucleotide polymorphisms (SNPs) in the growth arrest-specific gene 6 (Gas6; rs8191974) and adapter- related protein complex 3 subunit sigma-2 (Ap3s2; rs2028299) were associated with an increasedrisk for type 2 diabetes mellitus (T2DM). However, the association of these loci with T2DM has not been examined in Chinese populations. We performed a replication study to investigate the association of these susceptibility loci with T2DM in the Chinese population. We genotyped 1968 Chinese participants (996 with T2DM and 972controls) for rs8191974 in Gas6 and rs2028299 near Ap3s2, and examined their association with T2DM using a logistic regression analysis. We also analyzed the correlation of genotypes and clinical phenotypes. The distribution of the T allele of SNP rs8191974 in the Gas6 gene was significantly different between T2DM cases and controls when compared with the C allele (P |
| Databáze: | OpenAIRE |
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