CalliSpheres® drug-eluting beads (DEB) transarterial chemoembolization (TACE) is equally efficient and safe in liver cancer patients with different times of previous conventional TACE treatments: a result from CTILC study
| Autor: | J. Huang, Z.-C. Sun, C.-S. Shi, J. Fang, Z.-Y. Peng, X. Zhang, J.-H. Sun, W.-B. Ji, S.-H. Ying, D.-D. Zhu, J. Luo, Q.-M. Hou, J.-P. Zheng, G.-H. Zhou, W.-Q. Yu, J. Han, J.-S. Ji, T.-F. Li, H.-J. Hu, X.-H. Guo, Guoliang Shao, W.-J. Gu, H.-H. Xu, Y.-T. Chen, X. Wu, T.-Y. Hu, W.-H. Hu, Z.-H. Yu, J. Zhou, X.-X. Xie, G.-H. Cao, L. Li, H.-J. Du |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research medicine.medical_specialty medicine.drug_class Kaplan-Meier Estimate Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Chemoembolization Therapeutic Adverse effect Prospective cohort study Complete response Aged Drug Carriers Antibiotics Antineoplastic Bile acid Drug eluting beads business.industry Incidence (epidemiology) Liver Neoplasms General Medicine Middle Aged medicine.disease Microspheres Treatment Outcome 030104 developmental biology Oncology Doxorubicin 030220 oncology & carcinogenesis Female Liver function Neoplasm Recurrence Local Liver cancer business |
| Zdroj: | Clinical and Translational Oncology. 21:167-177 |
| ISSN: | 1699-3055 1699-048X |
| Popis: | To assess the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) in liver cancer patients with different times of previous conventional transarterial chemoembolization (cTACE) treatments. 367 liver cancer patients about to receive DEB-TACE treatment were enrolled in this prospective cohort study. All patients were divided into no previous cTACE group (NPC group), 1–2 times previous cTACE group (PC group) and triple or above previous cTACE group (TPC group) according to the times of previous cTACE treatments. There was no difference in complete response (CR) (P = 0.671) and objective response rate (ORR) (P = 0.062) among three groups. Additionally, no difference in overall survival (OS) among groups (P = 0.899) was found. As to liver function, most liver function indexes were deteriorative at 1 week after DEB-TACE operation, but returned to baseline at 1–3 months after DEB-TACE operation in all three groups, while percentage of abnormal total bile acid (TBA) patients was higher in TPC group than NPC and PC groups at 1–3 month post-DEB-TACE (P = 0.018). As for safety profiles, the incidence of pain during DEB-TACE operation was lower in TPC group compared to NPC and PC groups (P = 0.005), while no difference of other adverse events was found during and 1 month post-DEB-TACE treatment among three groups. DEB-TACE treatment was equally efficient and tolerated in liver cancer patients with different times of previous cTACE treatments. |
| Databáze: | OpenAIRE |
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