MALT lymphoma arising on a background of reactive pulmonary lymphoid hyperplasia in a patient with systemic lupus erythematosus
| Autor: | Reena Khiroya, Andrew Wotherspoon, Ute Laggner, Andrew G. Nicholson, Sujal R. Desai |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Histology reactive pulmonary lymphoid hyperplasia Lung Neoplasms Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine systemic lupus erythematosus Pseudolymphoma Antiphospholipid syndrome immune system diseases hemic and lymphatic diseases medicine Humans Lupus Erythematosus Systemic Lymphoid interstitial pneumonia MALT lymphoma Lupus erythematosus business.industry Amyloidosis 1103 Clinical Sciences General Medicine Lymphoma B-Cell Marginal Zone Middle Aged medicine.disease Lymphoma Cell Transformation Neoplastic 030228 respiratory system 030220 oncology & carcinogenesis Prednisolone Female business medicine.drug |
| Zdroj: | Histopathology. 72(4) |
| ISSN: | 1365-2559 |
| Popis: | Interstitial lung diseases are not infrequently complicated by development of malignancies and whilst most cases are carcinomas, rare cases of lymphoma have been reported,(1 2) these being diffuse large B-cell lymphomas and often associated with connective tissue disorders (CTDs). Reactive pulmonary lymphoid hyperplasia (RPLH), typically in the form of lymphoid interstitial pneumonia (LIP) often arises in patients with CTDs and only rarely shows malignant transformation,(3) with many of the early putative cases of transformation to MALT (mucosa-associated lymphoid tissue) lymphoma from LIP being lymphoma 'de novo'.(4) Herein we present a case of pulmonary non-Hodgkin lymphoma of MALT origin arising on a background RPLH with coexistent amyloidosis, confirmed by immunohistochemical and clonality studies. A 57 year old Caucasian female presented with chest pain and breathlessness at rest. She also described intermittent cough with small amounts of sputum, intermittent sweats, fatigue and joint pain in hands, feet, wrists, knees. She was known to have systemic lupus erythematosus (SLE) and SLE-related antiphospholipid syndrome for which she received immunosuppressive therapy including mycophenolate, prednisolone and hydroxychloroquin. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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