Effects of Pinacidil on Electrophysiological Properties of Epicardial Border Zone of Healing Canine Infarcts
| Autor: | Nicholas S. Peters, James Coromilas, Bernard Deruyter, Constantinos Costeas, Stephen M. Dillon, Andrew L. Wit |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Tachycardia
medicine.medical_specialty Potassium Channels genetic structures Vasodilator Agents Myocardial Infarction Ischemia Infarction Blood Pressure Anterior Descending Coronary Artery Electrocardiography chemistry.chemical_compound Dogs Heart Conduction System Physiology (medical) Internal medicine medicine Animals Myocardial infarction Electrodes Fluorescent Dyes Dose-Response Relationship Drug business.industry Pinacidil Heart medicine.disease Electric Stimulation Disease Models Animal Electrophysiology Injections Intra-Arterial chemistry Coronary occlusion Anesthesia Tachycardia Ventricular Cardiology medicine.symptom Electrophysiologic Techniques Cardiac Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 105:2309-2317 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000016292.14390.16 |
| Popis: | Background — K ATP channels, activated by ischemia, participate in the arrhythmogenic response to acute coronary occlusion. The function of these channels in border zones of healing infarcts, where arrhythmias also arise, has not been investigated. Do these channels remain maximally activated during infarct healing, or do they downregulate after a period of time? Both might preclude further activation. Methods and Results — Myocardial infarction was produced in dogs by ligation of the left anterior descending coronary artery. Impulse propagation in the epicardial border zone (EBZ) of 4-day-old healing infarcts was mapped during administration of pinacidil, a K ATP channel activator, directly into the EBZ coronary blood supply. Pinacidil restored conduction and excitability when the EBZ was initially inexcitable and had large regions of block (6 of 8 experiments). This allowed reentrant circuits to form in the EBZ, causing tachycardia (4 of 8 experiments ) . In hearts with an initially excitable EBZ, pinacidil shortened the effective refractory period and abolished conduction block at short cycle lengths (7 experiments). This effect prevented initiation of reentry (1 of 2 experiments). Conclusions — The response to pinacidil indicates that K ATP channels in the EBZ remain functional and can be activated to influence electrophysiological properties and arrhythmogenesis. |
| Databáze: | OpenAIRE |
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