The Eating Disorders Genetics Initiative (EDGI): study protocol
Autor: | Laura M. Thornton, Liselotte Petersen, Martin A. Kennedy, Cynthia M. Bulik, Richard Parker, Nicholas G. Martin, Patrick F. Sullivan, Lauren E. Harper, Zeynep Yilmaz, Allison L. Miller, Hannah L. Kennedy, Casey M. MacDermod, Janne Tidselbak Larsen, Lana Cleland, Jerry Guintivano, Jessica H. Baker, Jennifer Jordan, Jakob Grove |
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Rok vydání: | 2021 |
Předmět: |
RC435-571
Psychiatric genomics consortium Genome-wide association study Binge-eating disorder Social media Feeding and Eating Disorders Study Protocol 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic mental disorders medicine Humans Bulimia Nervosa/genetics Psychiatric genetics 030304 developmental biology Psychiatry Protocol (science) Genetics 0303 health sciences Genome-wide association Bulimia nervosa business.industry Feeding and Eating Disorders/genetics digestive oral and skin physiology Australia Anorexia nervosa medicine.disease United States Clinical trial Psychiatry and Mental health Eating disorders Anorexia nervosa (differential diagnoses) business 030217 neurology & neurosurgery Genome-Wide Association Study New Zealand |
Zdroj: | BMC Psychiatry, Vol 21, Iss 1, Pp 1-9 (2021) BMC Psychiatry Bulik, C M, Thornton, L M, Parker, R, Kennedy, H, Baker, J H, MacDermod, C, Guintivano, J, Cleland, L, Miller, A L, Harper, L, Larsen, J T, Yilmaz, Z, Grove, J, Sullivan, P F, Petersen, L V, Jordan, J, Kennedy, M A & Martin, N G 2021, ' The Eating Disorders Genetics Initiative (EDGI) : study protocol ', BMC Psychiatry, vol. 21, no. 1, 234 . https://doi.org/10.1186/s12888-021-03212-3 |
ISSN: | 1471-244X |
Popis: | BackgroundThe Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.MethodsA total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).DiscussionEDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver “actionable” findings that can be transformed into clinically meaningful insights.Trial registrationEDGI is a registered clinical trial: clinicaltrials.govNCT04378101. |
Databáze: | OpenAIRE |
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