Genetic Modulation of Hormone Levels and Life Span in Hybrids Between Laboratory and Wild-Derived Mice
| Autor: | Robert C. Dysko, James M. Harper, Steven N. Austad, Richard A. Miller, Stephen J. Durkee |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Leptin
Aging medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Longevity Animals Wild Mice Inbred Strains Biology Article Mice Chimera (genetics) Adrenal Cortex Hormones Animals Laboratory Internal medicine medicine Animals Sexual maturity Sexual Maturation Insulin-Like Growth Factor I Allele media_common Chimera Genetic heterogeneity Growth factor Body Weight Thyroxine Phenotype Endocrinology Geriatrics and Gerontology Hormone |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 61:1019-1029 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/61.10.1019 |
| Popis: | Previously we showed that mouse stocks derived from wild-caught progenitors are long-lived relative to genetically heterogeneous mice derived from laboratory-adapted strains. Here we replicate this life-span effect, and show that F2 hybrids between wild-derived and laboratory-derived stocks have intermediate survival patterns. Moreover, wild-derived mice are small, lean, and slow to mature, and have low serum insulin-like growth factor-I (IGF-I) relative to genetically heterogeneous mice. These traits, too, were at intermediate levels in the F2 hybrids. Furthermore, serum IGF-I at 6 months was a significant predictor of life span in two different populations of F2 hybrid mice. Pooling across stocks, life span was negatively correlated with body weight and serum IGF-I levels, and positively correlated with age at vaginal patency and serum leptin levels. Overall, these finding suggest that wild-derived mice harbor alleles that increase longevity, perhaps through effects on growth, maturation, and early-life hormone levels. |
| Databáze: | OpenAIRE |
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