Estrogen replacement therapy in postmenopausal women augments reactive hyperemia in the forearm by reducing angiotensin converting enzyme activity
| Autor: | Yukihito Higashi, Mikio Tsuda, Ichiro Kodama, Mitsuhiro Sanada, Keigo Nakagawa, Koso Ohama, Shota Sasaki, Tomohisa Sakashita |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Vasodilator Agents Bradykinin Blood lipids Hyperemia Peptidyl-Dipeptidase A Nitric Oxide Nitroglycerin chemistry.chemical_compound Forearm Internal medicine medicine Humans Reactive hyperemia Nitrites Estrogens Conjugated (USP) Nitrates biology business.industry Estrogen Replacement Therapy Angiotensin-converting enzyme Middle Aged Lipids Vasoprotective Plethysmography Postmenopause Vasodilation Blood pressure Endocrinology medicine.anatomical_structure chemistry Estrogen biology.protein Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Atherosclerosis. 158:391-397 |
| ISSN: | 0021-9150 |
| Popis: | The precise mechanism of the vasoprotective effect of estrogen replacement therapy in postmenopausal women is not fully understood. The present study sought to determine the role of nitric oxide (NO) and angiotensin-converting enzyme (ACE) in the vasodilator response of the forearm vessels induced by estrogen administration to postmenopausal women. Subjects were divided into two groups. One group received conjugated equine estrogen (0.625 mg daily) orally for 3 months (n=26), while the other received no treatment (control group, n=10). Forearm blood flow was measured by strain-gauge plethysmography. The concentrations of nitrite/nitrate (metabolites of NO), ACE activity, and lipid parameters were measured. Basal forearm blood flow, body weight, blood pressure, and heart rate were similar at baseline in both groups. After 3 months of estrogen administration, the maximal forearm blood flow response during reactive hyperemia and the serum level of nitrite/nitrate each showed a significant increase over baseline values: from 23.6+/-2.0 to 36.5+/-3.1 ml/min per 100 ml tissue (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect