Thyroid-related autoantibodies in Tunisian patients with type 1 diabetes
| Autor: | Mohamed Ouertani, Yosra Thabet, Amani Mankaï, Mohamed Taher Sfar, Lamia Boughammoura, Abdelaziz Harbi, Ibtissem Ghedira, Achouak Achour, Laarbi Chaieb, Wahiba Sakly |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Tunisia endocrine system diseases Adolescent medicine.medical_treatment Thyroid Gland Gastroenterology Iodide Peroxidase Thyroglobulin Endocrinology Internal medicine medicine Humans Child Antithyroglobulin antibody Aged Autoantibodies Retrospective Studies Type 1 diabetes biology business.industry Thyroid Autoantibody Infant Retrospective cohort study Receptors Thyrotropin General Medicine Middle Aged medicine.disease medicine.anatomical_structure Diabetes Mellitus Type 1 Hormone receptor Child Preschool biology.protein Female Antibody business |
| Zdroj: | Endocrine research. 37(2) |
| ISSN: | 1532-4206 |
| Popis: | To evaluate, retrospectively, the frequency of antithyroid antibodies (ATA) in patients with type 1 diabetes (T1D).Antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and antithyroid-stimulating hormone receptor antibodies (TSHR-Ab) were determined by enzyme-linked immunosorbent assay. Sera of 312 patients (166 children and 146 adults) with T1D were analyzed. Sera of 276 healthy subjects (87 children and 189 blood donors) served as controls.Out of 312 patients with T1D, 44 (14%) had ATA (TPO-Ab or TG-Ab or TSHR-Ab). The frequency of ATA in patients with T1D was significantly higher than in the control group (14% vs. 2.8%; p10(-5)). ATA were significantly more frequent in adult patients with T1D than in the blood donor group (20% vs. 1.6%; p10(-8)). The frequency of ATA in adult patients was significantly higher than in pediatric patients (20% vs. 9%; p=0.006). The frequency of TPO-Ab and TG-Ab was significantly higher in patients with T1D than in the control group (13.5% vs. 2%; p10(-8) and 7% vs. 2.2%, p=0.008), respectively. Out of 312 patients with T1D, only one had TSHR-Ab. The simultaneous presence of three autoantibodies was found in one patient with T1D.ATA were frequent in patients with T1D. Serological screening of autoimmune thyroid disease is suggested in patients with T1D. |
| Databáze: | OpenAIRE |
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