Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin
| Autor: | Hapizah Md Nawawi, R. Annuar, N.S. Osman, Khalid Yusoff, B. A K Khalid |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Atorvastatin Hypercholesterolemia Intercellular Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1 Hyperlipoproteinemia Type II Internal medicine medicine.artery E-selectin medicine Humans Pyrroles Prospective Studies Endothelial dysfunction Brachial artery biology Interleukin-6 Cell adhesion molecule Vascular disease business.industry Anticholesteremic Agents Middle Aged medicine.disease Vasodilation Endocrinology medicine.anatomical_structure Heptanoic Acids Multivariate Analysis biology.protein Female Endothelium Vascular E-Selectin Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Atherosclerosis. 169:283-291 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/s0021-9150(03)00193-x |
| Popis: | Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endothelial-dependent flow mediated dilatation (FMD) in patients with familial (FH) and non-familial hypercholesterolaemia (NFH). A total of 74 patients (27 FH and 47 NFH) were recruited. Fasting lipid profiles, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular-cellular adhesion molecule-1 (sVCAM-1), E-selectin, IL-6 and FMD were measured at baseline, 2 weeks, 3 and 9 months post-atorvastatin treatment (FH--80 mg/day, NFH--10 mg/day). In both groups, compared to baseline, sICAM-1 levels were significantly reduced at 2 weeks, further reduced at 3 months and maintained at 9 months (P |
| Databáze: | OpenAIRE |
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