Helicobacter pylori seropositivity in fibromyalgia syndrome
| Autor: | Yusuf Polat, Tufan Turk, Semih Akkaya, Fusun Sahin, Meral Türk, Elif Turhal, Nuray Akkaya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Questionnaires
Fibromyalgia serology Helicobacter pylori extragastric manifestations Seroepidemiologic Studies antibody Surveys and Questionnaires education.field_of_study biology Acute-phase protein article General Medicine Syndrome Middle Aged female priority journal Female disease severity medicine.symptom Antibody Alzheimer disease Fibromyalgia syndrome musculoskeletal diseases Adult medicine.medical_specialty Population letter immunoglobulin A antibody Enzyme-Linked Immunosorbent Assay Asymptomatic Helicobacter pylori infection Helicobacter infection Helicobacter Infections Rheumatology Internal medicine medicine Humans controlled study immunoglobulin G antibody human education Inflammation Helicobacter pylori business.industry questionnaire disease association Case-control study Case-Control Studies Enzyme-Linked Immunosorbent Assay/methods Fibromyalgia/*complications/*microbiology Helicobacter Infections/*complications/*microbiology Helicobacter pylori/*metabolism Immunoglobulin A/blood Immunoglobulin G/blood medicine.disease biology.organism_classification major clinical study clinical feature enzyme linked immunosorbent assay Immunoglobulin A Immunoglobulin G Immunology biology.protein business disease activity |
| Popis: | Although there are some studies suggesting relation between different types of infection and fibromyalgia syndrome (FM), there is presently no proof that FM is caused by an infection. Helicobacter pylori (HP) infection may cause extragastric manifestations. Inflammation is an important mediator of increased sympathetic nervous system activity and may lead to pain in fibromyalgia patients. In this study, we aimed to investigate the HP seropositivity in fibromyalgia patients compared with controls for possible role of HP infection in FM. Sixty-seven patients with fibromyalgia were evaluated. Two of them were excluded from the study because of high level of acute phase reactants. Sixty-five female patients with fibromyalgia and 41 randomly selected age-matched female healthy controls were enrolled to study. Serum HP IgA and IgG antibodies were measured by enzyme-linked immunosorbent assay technique. Fibromyalgia Impact Questionnaire was assessed in patients and controls. Seropositivity of HP IgG antibody in the fibromyalgia patients was significantly higher than in the control group. No statistically significant differences were found regarding the clinical features between fibromyalgia patients with HP IgG antibody and patients without IgG antibody. Our study suggests that former HP infection may have a role in the etiopathogenesis of fibromyalgia syndrome or may act as a triggering factor. However, high seroprevalence of HP in general population and prevalent asymptomatic infection make it difficult to interpret these results for the definite role of HP in FM. Highlighting the pathophysiologic mechanisms of FM will result in more effective treatment regimens. © Clinical Rheumatology 2010. |
| Databáze: | OpenAIRE |
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